{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:04:03Z","timestamp":1791835443490,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UBS Optimal Foundation","award":["GIFTS ID: 6088"],"award-info":[{"award-number":["GIFTS ID: 6088"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether an antimicrobial mouthrinse intervention reduces adverse pregnancy outcomes in a low\u2010resource rural area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A county\u2010level maternal health care hospital in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>Pregnant women of less than 20\u00a0weeks of gestation having periodontal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with periodontal disease were randomised into the intervention (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>232) and control group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>234). Participants in the intervention group were provided with free mouthrinse (alcohol\u2010free mouthrinse containing 0.7% cetylpyridinium chloride) throughout the pregnancy and given education on oral health. Women in the control group only received oral hygiene education. All participants had a periodontal re\u2010examination at the third trimester and were followed\u2010up to childbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary outcome was gestational age. Secondary outcomes included birthweight, periodontal disease score, pregnancy complications (small\u2010for\u2010gestational\u2010age, gestational hypertension, gestational diabetic mellitus, severe anaemia, premature rupture of membrane).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The general periodontal status of the intervention group at the third trimester was significantly better than that of the control group (measured by periodontal disease score: 11.26\u00a0\u00b1\u00a03.60 versus 11.92\u00a0\u00b1\u00a03.01; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04). There was no difference in pregnancy outcome between the two groups except\u00a0for premature rupture of the membranes. The women in the intervention group had a significantly reduced risk of premature rupture of the membranes compared with the control group (1.4 versus 5.7%, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content><jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.23, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.07\u20130.84; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The mouthrinse intervention during pregnancy improved periodontal health. The intervention did not lead to a change in gestational age but it reduced the rate of premature membrane rupture. Further studies are needed to explore the biological mechanism of this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Use of antiseptic mouthrinse during pregnancy may improve maternal oral health and pregnancy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14010","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T15:05:30Z","timestamp":1473865530000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Use of antiseptic mouthrinse during pregnancy and pregnancy outcomes: a randomised controlled clinical trial in rural China"],"prefix":"10.1111","volume":"123","author":[{"given":"H","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Public Health Fudan University Shanghai China"},{"name":"Key Laboratory of Public Health Safety Ministry of Education Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Public Health and Tropical Medicine Tulane University New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Su","sequence":"additional","affiliation":[{"name":"Eye &amp; ENT Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Peng","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Care Hospital Leping Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhu","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Care Hospital Leping Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wang","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Care Hospital Leping Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University Shanghai China"},{"name":"Key Laboratory of Public Health Safety Ministry of Education Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University Shanghai China"},{"name":"Global Health Institute Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_11_3_1","unstructured":"The United Nations Children's Fund and World Health Organization.Low birth weight: country regional and global estimates.New York:UNICEF;2004. 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