{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:45:36Z","timestamp":1792464336822,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T00:00:00Z","timestamp":1464652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether prolonged latency after preterm prelabour rupture of membranes (<jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content>) is associated with\u00a0an increased risk for adverse neurodevelopmental outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This is a secondary analysis of the randomised controlled trial of magnesium sulphate for the prevention of cerebral palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multicentre trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 1305 women with <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> were analysed, 1056 of whom had an interval of &lt;3\u00a0weeks between diagnosis and delivery and 249 of whom had an interval of \u22653\u00a0weeks between diagnosis and delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated whether the time interval between diagnosis of <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> and delivery was associated with an increased risk for adverse neurodevelopmental outcomes. Latency was analysed as a continuous variable and categorised by weeks of latency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary outcome was motor and mental Bayley scores of &lt;70 at 2\u00a0years of age. Secondary outcomes included motor and mental Bayley scores &lt;85 and mean Bayley scores. Logistic regression was used to control for confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the univariate analysis, motor and mental Bayley scores of &lt;70 were similar in the &lt;3\u00a0weeks (16.8 and 14.4%) and \u22653\u00a0weeks (15.3 and 14.1%) groups. In the regression analysis adjusting for confounding factors, <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> for \u22653\u00a0weeks was an independent risk factor for motor (adjusted odds ratio (aOR)\u00a02.12; 95%\u00a0confidence interval, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.29\u20133.49) and mental (aOR\u00a01.83, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.13\u20133.00) Bayley scores of &lt;70. Neonatal sepsis, gestational age at delivery, maternal education, and race were significantly associated with neurodevelopmental outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Whereas delivery at later gestational age is associated with improved prognosis for many outcomes, prolonged exposure to an intrauterine environment of <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> is an independent risk factor for adverse neurodevelopmental outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Prolonged <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> was associated with motor and mental Bayley scores of &lt;70.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14133","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T02:12:03Z","timestamp":1464747123000},"page":"1629-1635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Prolonged latency of preterm prelabour rupture of membranes and neurodevelopmental outcomes: a secondary analysis"],"prefix":"10.1111","volume":"123","author":[{"given":"D","family":"Drassinower","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AM","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Columbia University Medical Center New York NY 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