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Cost\u2010efficiency, defined as the additional cost per additional precancer detected of each strategy compared with the next most costly strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five strategies were identified as cost\u2010efficient, and are projected to increase the precancer detection rate between 18 and 57%, compared with current guidelines; however, the strategies did not uniformly require additional resources. Strategies involving HPV <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> testing required fewer resources, whereas <jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content>\u2010based strategies detected &gt;50% more precancers, but were more costly and required twice as many colposcopy referrals compared with the current guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Strategies involving biomarkers to triage younger women with minor cervical cytological lesions have the potential to detect additional precancers, yet the optimal strategy depends on the resources available as well as decision\u2010makers' and women's acceptance of additional screening procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Women with minor cervical lesions may be triaged more accurately and effectively using novel biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14135","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T07:20:43Z","timestamp":1465197643000},"page":"474-484","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Using novel biomarkers to triage young adult women with minor cervical lesions: a cost\u2010effectiveness analysis"],"prefix":"10.1111","volume":"124","author":[{"given":"K","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Health Management and Health Economics Institute of Health and Society University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SW","family":"S\u00f8rbye","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology University Hospital of North Norway Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IS","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Department of Health Management and Health Economics Institute of Health and Society University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EA","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Health Management and Health Economics Institute of Health and Society University of Oslo Oslo Norway"},{"name":"Center for Health Decision Science Harvard T.H. 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