{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T19:03:04Z","timestamp":1785610984489,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["UM.C\/625\/1\/HIR\/MOHE\/MED\/28"],"award-info":[{"award-number":["UM.C\/625\/1\/HIR\/MOHE\/MED\/28"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the tolerability of cervical insulin\u2010like growth factor binding protein 1 (<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101) and its value as a predictor of successful labour induction, compared with Bishop score and transvaginal ultrasound (<jats:styled-content style=\"fixed-case\">TVUS<\/jats:styled-content>) cervical length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A tertiary hospital in Malaysia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A cohort of 193 term nulliparous women with intact membranes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prior to labour induction, cervical fluid was obtained via a vaginal speculum and tested for <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101, followed by <jats:styled-content style=\"fixed-case\">TVUS<\/jats:styled-content> and finally Bishop score. After each assessment the procedure\u2010related pain was scored from 0 to 10. Cut\u2010off values for Bishop score and cervical length were obtained from the receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve. Multivariable logistic regression analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcomes measures<\/jats:title><jats:p>Vaginal delivery and vaginal delivery within 24 hours of starting induction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bedside <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 testing is better tolerated than Bishop score, but is less well tolerated than <jats:styled-content style=\"fixed-case\">TVUS<\/jats:styled-content> [median (interquartile range) of pain scores: 5 (4\u20135) versus 6 (5\u20137) versus 3 (2\u20133), respectively; <jats:italic>P<\/jats:italic> &lt; 0.001]. <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 independently predicted vaginal delivery (adjusted odds ratio, <jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content> 5.5; 95% confidence interval, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.3\u201312.9) and vaginal delivery within 24 hours of induction (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content> 4.9; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.1\u201311.6) after controlling for Bishop score (\u22654 or \u22655), cervical length (\u226429 or \u226427 mm), and other significant characteristics for which the Bishop score and <jats:styled-content style=\"fixed-case\">TVUS<\/jats:styled-content> were not predictive of vaginal delivery after adjustment. <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 has 81% sensitivity, 59% specificity, positive and negative predictive values of 82 and 58%, respectively, and positive and negative likelihood ratios of 2.0 and 0.3 for vaginal delivery, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 better predicted vaginal delivery than <jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TVUS<\/jats:styled-content>, and may help guide decision making regarding labour induction in nulliparous women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101: a stronger independent predictor of labour induction success than Bishop score or cervical sonography.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14175","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T11:01:17Z","timestamp":1467025277000},"page":"1274-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Insulin\u2010like growth factor binding protein 1, Bishop score, and sonographic cervical length: tolerability and prediction of vaginal birth and vaginal birth within 24 hours following labour induction in nulliparous women"],"prefix":"10.1111","volume":"124","author":[{"given":"N","family":"Vallikkannu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WK","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SZ","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PC","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.03.014"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Births: final data for 2013","volume":"64","author":"Martin JA","year":"2015","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_4_1","unstructured":"Health & Social Care Information Centre.NHS maternity statistics\u2014England 2013. \u201314[www.hscic.gov.uk\/catalogue\/PUB16725\/nhs-mate-eng-2013-14-summ-repo-rep.pdf]. 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