{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:35:47Z","timestamp":1789371347220,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T00:00:00Z","timestamp":1468800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of our study was to identify placental patterns associated with death before discharge or cerebral palsy in a large cohort of preterm infants with a high follow\u2010up rate at 2\u00a0years of corrected age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Population\u2010based monocentric study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>Monocentric study in the maternity unit of the University Hospital of Angers, France between 24<jats:sup>+0<\/jats:sup> and 33<jats:sup>+6<\/jats:sup>\u00a0weeks of gestation, between January 2008 and December 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>All singleton infants born alive with a placental examination were eligible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data (obstetric and neonatal) were collected prospectively through the <jats:styled-content style=\"fixed-case\">LIFT<\/jats:styled-content> cohort. Placental data were collected retrospectively from medical records. The main outcome measure was death before discharge or cerebral palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We did not find any significant association between severe inflammatory lesions on the placenta and death [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 1.49; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.55\u20134.01; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.43] or cerebral palsy (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.41; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.43\u20134.62; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.57). This lack of significant association persisted even after adjustment (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 0.9; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.20\u20132.30; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.54; <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 0.98; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.27\u20133.58; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results do not provide evidence for a significant association between severe inflammatory placental lesions and either death before discharge or cerebral palsy at 2\u00a0years of corrected age in preterm infants born at &lt;34\u00a0weeks of gestational age. Further studies remain necessary to confirm this result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>We found no significant association between inflammatory placental lesions and death or cerebral palsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14177","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T16:38:50Z","timestamp":1468859930000},"page":"1956-1963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of severe placental inflammation with death prior to discharge and cerebral palsy in preterm infants"],"prefix":"10.1111","volume":"123","author":[{"given":"N","family":"Huetz","sequence":"first","affiliation":[{"name":"Department of Neonatal Medicine Angers University Hospital Angers 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