{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:58:03Z","timestamp":1784350683031,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if higher\u2010volume, fixed\u2010dose administration of vasopressin further reduces blood loss at the time of minimally invasive myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised multicentre clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary\u2010care academic centres in the <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women undergoing conventional laparoscopic or robot\u2010assisted laparoscopic myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All participants received the same 10\u2010unit (U) dose of vasopressin, but were randomly assigned to one of two groups: (i) received 200\u00a0ml of diluted vasopressin solution (20\u00a0U in 400\u00a0ml normal saline), and (ii) received 30\u00a0ml of concentrated vasopressin solution (20\u00a0U in 60\u00a0ml normal saline).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary study outcome was estimated blood loss; the study was powered to detect a 100\u2010ml difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 152 women were randomised; 76 patients in each group. Baseline demographics were similar between groups. The primary outcome of intraoperative blood loss was not significantly different, as measured by three parameters: surgeon estimate (mean estimated blood loss 178\u00a0\u00b1\u00a0265\u00a0ml and 198\u00a0\u00b1\u00a0232\u00a0ml, dilute and concentrated groups respectively, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.65), suction canister\u2010calculated blood loss, or change in haematocrit levels. There were no vasopressin\u2010related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both dilute and concentrated vasopressin solutions that use the same drug dosing demonstrate comparable safety and tolerability when administered for minimally invasive myomectomy; however, higher volume administration of vasopressin does not reduce blood loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>This randomised trial failed to show benefit of high\u2010volume dilute vasopression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14179","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T14:00:26Z","timestamp":1467295226000},"page":"262-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Dilute versus concentrated vasopressin administration during laparoscopic myomectomy: a randomised controlled trial"],"prefix":"10.1111","volume":"124","author":[{"given":"SL","family":"Cohen","sequence":"first","affiliation":[{"name":"Division of Minimally Invasive Gynecologic Surgery Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Senapati","sequence":"additional","affiliation":[{"name":"Division of Gynecological Pain and Minimally Invasive Surgery NorthShore University HealthSystem Evanston IL &amp; 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