{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:12:27Z","timestamp":1787508747811,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003197","name":"Agenzia Italiana del Farmaco, Ministero della Salute","doi-asserted-by":"publisher","award":["H85E08000200005"],"award-info":[{"award-number":["H85E08000200005"]}],"id":[{"id":"10.13039\/501100003197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (\n                      <jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>\n                      ), and the outcomes associated with such procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University and hospital clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>\n                      Pregnant women with\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Temporal trends were analysed by analysis of variance and by the Chi\u2010square test for trend. Quantitative variables were compared by Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test and categorical data by the Chi\u2010square test, with odds ratios and 95% confidence intervals calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>\n                      Rate of invasive testing, intrauterine death,\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      transmission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between 2001 and 2015, among 2065 pregnancies in women with\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      , 113 (5.5%) had invasive tests performed. The procedures were conducted under antiretroviral treatment in 99 cases (87.6%), with a significant increase over time in the proportion of tests performed under highly active antiretroviral therapy (\n                      <jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content>\n                      ) (100% in 2011\u20132015). Three intrauterine deaths were observed (2.6%), and 14 pregnancies were terminated because of fetal anomalies. Among 96 live newborns, eight had no information available on HIV status. Among the remaining 88 cases with either amniocentesis (\n                      <jats:italic>n<\/jats:italic>\n                      = 75),\n                      <jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      = 12), or both (\n                      <jats:italic>n<\/jats:italic>\n                      = 1), two\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      transmissions occurred (2.3%). No\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      transmission occurred among the women who were on\n                      <jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content>\n                      at the time of invasive testing, and none after 2005.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The findings reinforce the assumption that invasive prenatal testing does not increase the risk of\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      vertical transmission among pregnant women under suppressive antiretroviral treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>\n                      No\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      transmission occurred among women who underwent amniocentesis or\n                      <jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>\n                      under effective anti\u2010\n                      <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                      regimens.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.14183","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T05:20:44Z","timestamp":1466400044000},"page":"1218-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Amniocentesis and chorionic villus sampling in HIV\u2010infected pregnant women: a multicentre case series"],"prefix":"10.1111","volume":"124","author":[{"given":"M","family":"Floridia","sequence":"first","affiliation":[{"name":"Department of Therapeutic Research and Medicines Evaluation Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Masuelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Neonatology Citt\u00e0 della Salute e della Scienza Hospital University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Meloni","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Obstetrics S. Giovanni di Dio Hospital University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Cetin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Luigi Sacco Hospital University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Tamburrini","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AF","family":"Cavaliere","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Dalzero","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology DMSD San Paolo Hospital Medical School University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sansone","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Dentistry Science University Federico II, Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Alberico","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Guerra","sequence":"additional","affiliation":[{"name":"St. Orsola\u2010Malpighi General Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Spinillo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Chiad\u00f2 Fiorio Tin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Neonatology Citt\u00e0 della Salute e della Scienza Hospital University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ravizza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology DMSD San Paolo Hospital Medical School University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of The Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f9b67a"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1093\/cid\/civ578","article-title":"No perinatal HIV\u20101 transmission from women with effective antiretroviral therapy starting before conception","volume":"61","author":"Mandelbrot L","year":"2015","journal-title":"Clin Infect Dis"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/2673717"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199805000-00013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199912000-00001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.087"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.045"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2008.04.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.049"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/914272"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268806006066"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000209900.05126.25"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.726"},{"key":"e_1_2_6_15_1","unstructured":"Agenzia Nazionale per i Servizi Sanitari Regionali (AGENAS): Diagnosi prenatale ed ecografia in gravidanza.Linee Guida nazionali di Riferimento \u2013 Anno 2013. [www.agenas.it\/diagnosi-prenatale-ed-ecografia-in-gravidanza]. Accessed 29 October 2015."},{"key":"e_1_2_6_16_1","unstructured":"HIV\/AIDS Italian Expert Panel.Linee Guida Italiane sull'utilizzo dei farmaci antiretrovirali e sulla gestione diagnostico\u2010clinica delle persone con infezione da HIV\u20101. [www.salute.gov.it\/imgs\/C_17_pubblicazioni_2261_allegato.pdf]. Accessed 26 April 2016."},{"key":"e_1_2_6_17_1","unstructured":"Ministero della Salute\u2014Direzione Generale della digitalizzazione del sistema informativo sanitario e della statistica.Certificato di assistenza al parto (CeDAP). Analisi dell'evento nascita\u2014Anno 2013. 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