{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:22:53Z","timestamp":1792797773628,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T00:00:00Z","timestamp":1473033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hvidovre Hospital Research Fund","id":[{"id":"https:\/\/ror.org\/00edrn755","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Finox"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Background<\/jats:title>\n \n Approximately 50 000 oocyte donation (\n OD<\/jats:styled-content>\n ) treatment cycles are now performed annually in Europe and the\n US<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To ascertain whether the risk of adverse obstetric and perinatal\/neonatal outcomes is higher in pregnancies conceived by\n OD<\/jats:styled-content>\n than in pregnancies conceived by conventional in\u2010vitro fertilisation (\n IVF<\/jats:styled-content>\n )\/intracytoplasmic sperm injection (\n ICSI<\/jats:styled-content>\n ) or spontaneously.\n <\/jats:p>\n <\/jats:sec>\n \n Search Strategy<\/jats:title>\n \n A systematic search was performed in the PubMed, Cochrane and Embase databases from 1982\u20132016. Primary outcomes were hypertensive disorders of pregnancy, pre\u2010eclampsia (\n PE<\/jats:styled-content>\n ), gestational diabetes mellitus, postpartum haemorrhage, caesarean section, preterm birth, low birthweight and small for gestational age.\n <\/jats:p>\n <\/jats:sec>\n \n Selection criteria<\/jats:title>\n \n Inclusion criteria were original studies including at least five\n OD<\/jats:styled-content>\n pregnancies with a control group of pregnancies conceived by conventional\n IVF<\/jats:styled-content>\n \/\n ICSI<\/jats:styled-content>\n or spontaneous conception, and case series with >500 cases reporting one or more of the selected complications. Studies not adjusting for plurality were excluded.\n <\/jats:p>\n <\/jats:sec>\n \n Data collection and analysis<\/jats:title>\n Thirty\u2010five studies met the inclusion criteria. A random\u2010effects model was used for the meta\u2010analyses.<\/jats:p>\n <\/jats:sec>\n \n Main results<\/jats:title>\n \n For\n OD<\/jats:styled-content>\n pregnancies versus conventional\n IVF<\/jats:styled-content>\n \/\n ICSI<\/jats:styled-content>\n pregnancies the risk of\n PE<\/jats:styled-content>\n was adjusted odds ratio (\n AOR<\/jats:styled-content>\n ) 2.11 (95%\n CI<\/jats:styled-content>\n , 1.42\u20133.15) in singleton and\n AOR<\/jats:styled-content>\n 3.31 (95%\n CI<\/jats:styled-content>\n , 1.61\u20136.80) in multiple pregnancies. The risks of preterm birth and low birthweight in singletons were\n AOR<\/jats:styled-content>\n 1.75 (95%\n CI<\/jats:styled-content>\n , 1.39\u20132.20) and 1.53 (95%\n CI<\/jats:styled-content>\n , 1.16\u20132.01), respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n OD<\/jats:styled-content>\n conceptions are associated with adverse obstetric and neonatal outcomes. To avoid the additional increase in risk from multiplicity, single\u2010embryo transfer should be the choice of option in\n OD<\/jats:styled-content>\n cycles.\n <\/jats:p>\n <\/jats:sec>\n \n Tweetable abstract<\/jats:title>\n Oocyte donation pregnancies have increased risk of a range of obstetric and neonatal complications.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.14257","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T03:12:58Z","timestamp":1473045178000},"page":"561-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":166,"title":["Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"124","author":[{"given":"M","family":"Storgaard","sequence":"first","affiliation":[{"name":"Fertility Clinic Copenhagen University Hospital Hvidovre Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Loft","sequence":"additional","affiliation":[{"name":"Fertility Clinic Section 4071 Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bergh","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Departments of Obstetrics and Gynaecology Institute of Clinical Sciences Sahlgrenska Academy Gothenburg University Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UB","family":"Wennerholm","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynaecology Institute of Clinical Sciences Sahlgrenska Academy Gothenburg University Sahlgrenska University Hospital\/East Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"S\u00f6derstr\u00f6m\u2010Anttila","sequence":"additional","affiliation":[{"name":"V\u00e4est\u00f6liitto Fertility Clinic Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LB","family":"Romundstad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology IVF Unit St Olav's University Hospital Trondheim Norway"},{"name":"Department of Public Health Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Aittomaki","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Helsinki University Central Hospital (HUCH) and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Oldereid","sequence":"additional","affiliation":[{"name":"Section for Reproductive Medicine Department of Gynecology Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Forman","sequence":"additional","affiliation":[{"name":"Section of Biostatistics Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pinborg","sequence":"additional","affiliation":[{"name":"Fertility Clinic Copenhagen University Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/307174a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.059"},{"key":"e_1_2_6_4_1","first-page":"585","article-title":"Comparison of obstetric outcomes in recipients of donor oocytes vs. women of advanced maternal age with autologous oocytes","volume":"52","author":"Henne MB","year":"2007","journal-title":"J Reprod Med"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.746298"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10096.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-42"},{"key":"e_1_2_6_8_1","first-page":"233","article-title":"Assisted reproductive technology in Europe, 2011: results generated from European registers by ESHRE","volume":"31","author":"European IVF\u2010Monitoring Consortium (EIM) European Society of Human Reproduction and Embryology (ESHRE)","year":"2016","journal-title":"Hum Reprod"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/655978"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.03.010"},{"key":"e_1_2_6_11_1","unstructured":"Division of Reproductive Health NCfCDPaHP.2013 Assisted Reproductive Technology National Summary Report. 2015. 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