{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:12:55Z","timestamp":1790305975212,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"LSHTM Clinical Trials Unit"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Postpartum haemorrhage is the leading cause of maternal mortality. Tranexamic acid (<jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>) reduces surgical haemorrhage and the risk of death in bleeding trauma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the effects of <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content> on risk of postpartum haemorrhage and other clinically relevant outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>We searched the <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CENTRAL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, PubMed, ClinicalTrials.gov and <jats:styled-content style=\"fixed-case\">WHO ICTRP<\/jats:styled-content> electronic databases to May 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Randomised controlled trials comparing <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content> with no <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content> or placebo in women giving birth vaginally or by caesarean section.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Two authors extracted data and assessed the risk of bias for each trial. Because of data concerns we did not conduct a meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>We found 26 trials including a total of 4191 women. Examination of the trial reports raised concerns about the quality of the data. Eight trial reports contained identical or similar text and there were important data inconsistencies in several trials. Two trials did not have ethics committee approval. Meta\u2010analysis of baseline variables suggested that randomisation was inadequate in many trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no reliable evidence that <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content> prevents postpartum haemorrhage during childbirth. Many of the trials conducted to date are small, low quality and contain serious flaws.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>No evidence that <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content> prevents postpartum haemorrhage. Existing trials are unreliable, with serious flaws.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14267","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:03:06Z","timestamp":1472083386000},"page":"1745-1752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Does tranexamic acid prevent postpartum haemorrhage? 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