{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:58:39Z","timestamp":1789340319780,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterise the current clinical practice patterns regarding the use of magnesium sulphate (Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub>) for eclampsia prevention and treatment in a multi\u2010country network of health facilities and compare with international recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A total of 147 health facilities in 15 countries across Africa, Latin America and Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Heads of obstetric departments or maternity units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anonymous online and paper\u2010based survey conducted in 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Availability and use of Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub>; availability of a formal clinical protocol for Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> administration; and Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> dosing regimens for eclampsia prevention and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Magnesium sulphate and a formal protocol for its administration were reported to be always available in 87.4% and 86.4% of all facilities, respectively. Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> was used for the treatment of mild pre\u2010eclampsia, severe pre\u2010eclampsia and eclampsia in 24.3%, 93.5% and 96.4% of all facilities, respectively. Regarding the treatment of severe pre\u2010eclampsia, 26.4% and 7.0% of all facilities reported using dosing regimens that were consistent with Zuspan and Pritchard regimens, respectively. Across regions, intramuscular maintenance regimens were more commonly used in the African region (45.7%) than in the Latin American (3.0%) and Asian (22.9%) regions, whereas intravenous maintenance regimens were more often used in the Latin American (94.0%) and Asian (60.0%) regions than in the African region (21.7%). Similar patterns were found for the treatment of eclampsia across regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The reported clinical use of Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> for eclampsia prevention and treatment varied widely, and was largely inconsistent with current international recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> regimens for eclampsia prevention and treatment in many hospitals are inconsistent with international 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