{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:22:59Z","timestamp":1792797779757,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ammalife"},{"name":"Elly Appeal (Barts Charity)","id":[{"id":"https:\/\/ror.org\/0513pp416","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Background<\/jats:title>\n \n There is a dearth of data on the clinical features and outcomes of active tuberculosis (\n TB<\/jats:styled-content>\n ) in pregnancy. Studies have shown varied results and the relationship between\n TB<\/jats:styled-content>\n and adverse pregnancy outcomes remains unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n We conducted a systematic review and meta\u2010analysis to evaluate pregnancy outcomes associated with\n TB<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Search strategy<\/jats:title>\n \n Major databases were searched from inception until December 2015 without restrictions using the terms: \u2018\n TB<\/jats:styled-content>\n \u2019, \u2018pregnancy\u2019, \u2018maternal morbidity\u2019, \u2018mortality\u2019 and \u2018perinatal morbidity\u2019, \u2018mortality\u2019.\n <\/jats:p>\n <\/jats:sec>\n \n Selection criteria<\/jats:title>\n We included studies that compared the outcomes of pregnant women with and without active TB.<\/jats:p>\n <\/jats:sec>\n \n Data collection and analysis<\/jats:title>\n \n We computed odds ratios for maternal and perinatal complications, and pooled them using a random effects model. We assessed for heterogeneity using chi\u2010squared tests and evaluated its magnitude using the\n I<\/jats:italic>\n 2<\/jats:sup>\n statistic. We used the Newcastle\u2013Ottawa scale for quality assessment.\n <\/jats:p>\n <\/jats:sec>\n \n Main results<\/jats:title>\n \n Thirteen studies, including 3384 pregnancies with active\n TB<\/jats:styled-content>\n and 119\u00a0448 without\n TB<\/jats:styled-content>\n were included. Compared with pregnant women without\n TB<\/jats:styled-content>\n , pregnant women with active\n TB<\/jats:styled-content>\n was associated with increased odds of maternal morbidity [odds ratio (\n OR<\/jats:styled-content>\n ) 2.8, 95%\n CI<\/jats:styled-content>\n 1.7\u20134.6;\n I<\/jats:italic>\n 2\u00a0<\/jats:sup>\n =\u00a060.3%], anaemia (\n OR<\/jats:styled-content>\n 3.9, 95%\n CI<\/jats:styled-content>\n 2.2\u20136.7;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a029.8%), caesarean delivery (\n OR<\/jats:styled-content>\n 2.1, 95%\n CI<\/jats:styled-content>\n 1.2\u20133.8;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a061.1%), preterm birth (\n OR<\/jats:styled-content>\n 1.7, 95%\n CI<\/jats:styled-content>\n 1.2\u20132.4;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a066.5%), low birth weight (\n OR<\/jats:styled-content>\n 1.7, 95%\n CI<\/jats:styled-content>\n 1.2\u20132.4;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a053.7%), birth asphyxia (\n OR<\/jats:styled-content>\n 4.6, 95%\n CI<\/jats:styled-content>\n 2.4\u20138.6;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a046.3), and perinatal death (\n OR<\/jats:styled-content>\n 4.2, 95%\n CI<\/jats:styled-content>\n 1.5\u201311.8;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a057.2%).\n <\/jats:p>\n <\/jats:sec>\n \n Author's conclusion<\/jats:title>\n \n Active\n TB<\/jats:styled-content>\n in pregnancy is associated with adverse maternal and fetal outcomes. Early diagnosis of\n TB<\/jats:styled-content>\n is important to prevent significant maternal and perinatal complications.\n <\/jats:p>\n <\/jats:sec>\n \n Tweetable abstract<\/jats:title>\n Active tuberculosis in pregnancy is associated with adverse maternal and perinatal outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.14408","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T19:09:59Z","timestamp":1479236999000},"page":"727-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":142,"title":["Maternal and perinatal mortality and morbidity associated with tuberculosis during pregnancy and the postpartum period: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"124","author":[{"given":"S","family":"Sobhy","sequence":"first","affiliation":[{"name":"Women's Health Research Unit Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZOE","family":"Babiker","sequence":"additional","affiliation":[{"name":"Department of Infection Royal London Hospital Barts Health NHS Trust London UK"},{"name":"Department of Internal Medicine College of Medicine and Health Sciences United Arab Emirates University Al Ain UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zamora","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"Multidisciplinary Evidence Synthesis Hub (mEsh) Centre of Primary Care and Public Health Blizard Institute Barts and The London School of Medicine and Dentistry London UK"},{"name":"Clinical Biostatistics Unit Hospital Ramon y Cajal (IRYCIS) and CIBER Epidemiology and Public Health Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Khan","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"Multidisciplinary Evidence Synthesis Hub (mEsh) Centre of Primary Care and Public Health Blizard Institute Barts and The London School of Medicine and Dentistry London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kunst","sequence":"additional","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Global Tuberculosis Report 2014.2014[http:\/\/apps.who.int\/iris\/bitstream\/10665\/137094\/1\/9789241564809_eng.pdf]. 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