{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:02:44Z","timestamp":1791849764649,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Research Center of Tabriz University of Medical Sciences"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effectiveness and safety of oxytocin to reduce blood loss during abdominal myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Double\u2010blind randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Obstetrics and Gynecologic University Medical Centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eighty healthy women candidates for abdominal myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women were randomly assigned to two groups. In the study group (<jats:italic>n\u00a0<\/jats:italic>=\u00a040) oxytocin 30 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content> in 500\u00a0ml normal saline; and in the placebo group (<jats:italic>n\u00a0<\/jats:italic>=\u00a040) pure normal saline was administered during myomectomy. The main outcome measures\u00a0were peri\u2010operative blood loss and rates of blood transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>Estimated intra\u2010operative blood loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estimated intra\u2010operative blood loss in the study group (189.5\u00a0\u00b1\u00a016.72\u00a0ml) was significantly lower than the placebo group (692.25\u00a0\u00b1\u00a089.93\u00a0ml) (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 672.54\u2013711.96; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001).The need for blood transfusion was significantly lower in the study group. Blood transfusions were required for three (7.5%) women in the study group and 10 (25%) women in the placebo group (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 15.5\u201334.5; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intra\u2010operative oxytocin infusion appears to be safe and effective in decreasing blood loss during abdominal myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Intra\u2010operative oxytocin is effective in decreasing blood loss during abdominal myomectomy<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14416","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T18:14:22Z","timestamp":1479320062000},"page":"292-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of oxytocin infusion on reducing 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