{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:29:05Z","timestamp":1779100145813,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of maternal low flow oxygen administration during the second stage of labour on umbilical cord artery <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A tertiary teaching hospital in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women in the second stage of labour with no complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>About 443 women were randomly allocated to receive either supplemental oxygen at a flow rate of 2\u00a0l\/min or a sham supplementation by nasal cannula. Healthcare providers, women and outcome assessors were blinded to allocation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Umbilical cord artery <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and fetal heart rate (<jats:styled-content style=\"fixed-case\">FHR<\/jats:styled-content>) pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics were similar between the two groups. There were no significant differences between the two groups in the umbilical cord artery <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> [median 7.261, interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>) 7.228\u20137.295 versus 7.266 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 7.232\u20137.297), <jats:italic>P\u00a0<\/jats:italic>=\u00a00.64], the proportion with <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> less than 7.2 [30\/219 versus 34\/224, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.66, <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> (relative risk) 0.9, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.57\u20131.42], and the proportion with normal <jats:styled-content style=\"fixed-case\">FHR<\/jats:styled-content> pattern (147\/219 versus 153\/224, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.79, <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.98, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.86\u20131.12). Maternal partial pressure of dissolved oxygen was significantly higher in the oxygen group than in the sham group [median 150.0\u00a0mmHg (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 142.6\u2013156.7) versus 112.0 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 104.8\u2013118.3), <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001], whereas carbon dioxide was significantly lower in the oxygen group than in the sham group (mean difference \u22121.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22122.1 to \u22120.1, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of 2\u00a0l\/min maternal oxygen during the second stage of labour did not adversely affect either the umbilical artery <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> or the <jats:styled-content style=\"fixed-case\">FHR<\/jats:styled-content> pattern distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>No difference in abnormal fetal acid base or normal heart rate if maternal O<jats:sub>2<\/jats:sub> given, randomised trial finds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14418","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T04:31:02Z","timestamp":1487737862000},"page":"678-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The effect of maternal low flow oxygen administration during the second stage of labour on umbilical cord artery <scp>pH<\/scp>: a randomised controlled trial"],"prefix":"10.1111","volume":"124","author":[{"given":"G","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Navy General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Navy General Hospital Beijing China"},{"name":"Department of Anaesthesia Chaoyang Chinese Traditional and Western Medicine Emergency Medical Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Navy General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Navy General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Navy General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Chuai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Navy General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Navy General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"issue":"12","key":"e_1_2_7_2_1","first-page":"CD000136","article-title":"Maternal oxygen administration for fetal distress","author":"Fawole B","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.01.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.01.058"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.01.057"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12804"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12805"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.06.084"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000164474.03350.7c"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182004fa9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90558-8"},{"issue":"167","key":"e_1_2_7_12_1","first-page":"90","article-title":"The correlation of intrapartum maternal oxygen administration and umbilical cord blood gas values","volume":"76","author":"Sirimai K","year":"1997","journal-title":"Acta Obstet Gynecol Scand"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10229"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181aef106"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200611000-00058"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03335.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12290"},{"key":"e_1_2_7_18_1","first-page":"404","article-title":"Oxygen administration in labour and cord acid\u2010base status at birth","volume":"4","author":"Jozwik M","year":"2000","journal-title":"Med Wieku Rozwoj"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/61.3.250"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90624-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90631-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.11.007"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1983.244.6.H749"},{"key":"e_1_2_7_24_1","volume-title":"Eighth edition: physiology","author":"Zhu D","year":"2013"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12268"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.14418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.14418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:11:59Z","timestamp":1696381919000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.14418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/1471-0528.14418"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.14418","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]},"assertion":[{"value":"2016-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}