{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:39:29Z","timestamp":1788565169784,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["09\/55\/38"],"award-info":[{"award-number":["09\/55\/38"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop a set of core outcomes for studies on pregnant women with epilepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Delphi consensus study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Healthcare professionals, and patient representatives with lived experience of epilepsy in the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a modified Delphi method and a consultation meeting to achieve consensus. Potential outcomes were identified by systematic review, and were scored using a Likert scale anchored between 1 (least important) and 5 (most important). We included outcomes that scored \u22654 by &gt;70% of participants, and outcomes that scored \u22642 by &lt;15% of participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Outcomes in studies on epilepsy in pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five healthcare professionals completed the first round, 48 (64%) completed the second round, and 37 (49%) completed the third round of the survey. Twenty\u2010four patient representatives participated. The final core outcome set included 31 outcomes in three domains: neurological, offspring, and obstetric. Outcomes in the neurological domain were seizure control in pregnancy and postpartum, status epilepticus, maternal mortality, drowning, sudden unexpected death in epilepsy, postnatal depression, and quality of life. Offspring domain included congenital abnormalities (major and minor), fetal anticonvulsant syndrome, neurodevelopment, autism disorder, neonatal clinical complications, admission to a neonatal intensive care unit, and anthropometric measurements. The obstetric domain included live birth, stillbirth, miscarriage, ectopic, termination of pregnancy, admission to a high dependency or intensive care unit, breastfeeding, mode of delivery, preterm birth, pre\u2010eclampsia, and eclampsia. Outcomes specific for studies on anti\u2010epileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) included maternal <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> toxicity, <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> compliance, neonatal withdrawal symptoms, and neonatal haemorrhagic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Embedding this core set in future clinical trials will promote the standardisation of reporting to inform clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A Delphi method identifying core outcomes for epilepsy in pregnancy. Final core set includes 31 outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14430","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T04:14:48Z","timestamp":1479356088000},"page":"661-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Development of a core outcome set for epilepsy in pregnancy (E\u2010<scp>CORE<\/scp>): a national multi\u2010stakeholder modified Delphi consensus study"],"prefix":"10.1111","volume":"124","author":[{"given":"BH","family":"Al Wattar","sequence":"first","affiliation":[{"name":"Women's Health Research Unit Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tamilselvan","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Khan","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kelso","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sinha","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AM","family":"Pirie","sequence":"additional","affiliation":[{"name":"Birmingham Women's Hospital Birmingham UK"},{"name":"University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"McCorry","sequence":"additional","affiliation":[{"name":"University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Khan","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"Multidisciplinary Evidence Synthesis Hub (mEsh) Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"The CROWN Initiative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Thangaratinam","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"Multidisciplinary Evidence Synthesis Hub (mEsh) Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Antiepileptic Drug Management in Pregnancy (EMPIRE) Collaborative Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00045-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000195888.51845.80"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70107-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.10.017"},{"issue":"5","key":"e_1_2_11_6_1","first-page":"ED000041","article-title":"The COMET (Core Outcome Measures in Effectiveness Trials) initiative: its role in improving cochrane reviews","author":"Williamson P","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-199"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000393"},{"key":"e_1_2_11_9_1","unstructured":"COMET.COMET database [Internet][www.comet-initiative.org\/studies\/details\/393?result=true]. 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