{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:21:13Z","timestamp":1789924873797,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Several randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) compared induction of labour with expectant management in non\u2010diabetic women with suspected fetal macrosomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effects of labour induction for suspected fetal macrosomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Literature search in electronic databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>We included all <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s of suspected fetal macrosomia comparing labour induction with expectant management in term pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>The primary outcome was the incidence of caesarean delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Four <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s, including 1190 non\u2010diabetic women with suspected fetal macrosomia at term, were analysed. Pooled data did not show a significant difference in incidence of caesarean delivery [relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) 0.91, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.76\u20131.09], operative and spontaneous vaginal delivery, shoulder dystocia, intracranial haemorrhage, brachial plexus palsy, Apgar score &lt;7 at 5 min, cord blood <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> &lt;7, and mean birth weight comparing women who received induction of labour with those who were managed expectantly. The induction group had a significantly lower time to delivery (mean difference \u22127.55 days, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22128.20 to \u22126.89), lower rate of birth weight \u22654000 g (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.50, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.42\u20130.59) and \u22654500 g (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.21, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.11\u20130.39), and lower incidence of fetal fractures (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.17, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.03\u20130.79) compared with expectant management group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Induction of labour \u226538 weeks for suspected fetal macrosomia is associated with a significant decrease in fetal fractures, and therefore can be considered as a reasonable option.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>#Induction of labour for #macrosomia improves neonatal outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14435","type":"journal-article","created":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T01:12:56Z","timestamp":1480986776000},"page":"414-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Induction of labour for suspected macrosomia at term in non\u2010diabetic women: a systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"124","author":[{"given":"ER","family":"Magro\u2010Malosso","sequence":"first","affiliation":[{"name":"Department of Health Science Division of Pediatrics, Obstetrics and Gynecology Careggi Hospital University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Saccone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry School of Medicine University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Sidney Kimmel Medical College of Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Navathe","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Sidney Kimmel Medical College of Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Di Tommaso","sequence":"additional","affiliation":[{"name":"Department of Health Science Division of Pediatrics, Obstetrics and Gynecology Careggi Hospital University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Berghella","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Sidney Kimmel Medical College of Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"158","article-title":"Macrosomia \u2013 maternal characteristics and infant complications","volume":"66","author":"Spellacy WN","year":"1985","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_3_1","unstructured":"ACOG Practice Bulletin"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100192"},{"key":"e_1_2_6_5_1","first-page":"CD000938","article-title":"Induction of labour at or near term for suspected fetal macrosomia","volume":"5","author":"Boulvain M","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_6_1","unstructured":"HigginsJPT AltmanDG SterneJAC.Cochrane Handbook for Systematic Reviews of Interventions version 5.1.0(update March 2011). 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