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Women were followed until 2009 or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cox proportional hazard regression model was applied to estimate hazard ratios (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s) with 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary outcome was all\u2010cause mortality during follow up. Secondary outcomes were cause\u2010specific mortality (cardiovascular mortality, deaths due to cancer, external causes or mental and behavioural disorders).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 999\u00a0161 women with singleton births, 13\u00a0397 (1.3%) experienced <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>. During a median follow up of 26\u00a0years (25\u00a0902\u00a0036 person\u2010years), 43\u00a0470 women died (4.4%). Women exposed to <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content> had a lower risk of long\u2010term all\u2010cause mortality compared with women without <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content> (crude <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.82; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.75\u20130.90). When adjusting for confounders, this reduction was no longer significant (adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.92; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.84\u20131.01). Women exposed to <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content> had a similar risk of cardiovascular death as women not exposed (adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.04; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.83\u20131.29), but a lower long\u2010term risk of death from cancer (adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.86; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.75\u20130.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large population\u2010based cohort study, <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content> was not associated with an increased risk of long\u2010term all\u2010cause mortality. Women exposed to <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content> had no increase in mortality due to cardiovascular disease, but had a reduced risk of death from cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Population\u2010based cohort study: Hyperemesis was not associated with an increased risk of long\u2010term mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14454","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T11:55:32Z","timestamp":1481975732000},"page":"1080-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hyperemesis gravidarum and long\u2010term mortality: a population\u2010based cohort study"],"prefix":"10.1111","volume":"124","author":[{"given":"S","family":"Fossum","sequence":"first","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Ulleval Oslo 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