{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:26:07Z","timestamp":1783164367162,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National University Hospital, Singapore","award":["OGPFF 2013"],"award-info":[{"award-number":["OGPFF 2013"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association of first pregnancy preterm prelabour rupture of membranes (<jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content>) with adverse maternal and perinatal outcomes in the next pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Grampian, Scotland, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women with first deliveries recorded in the Aberdeen Maternity Neonatal Databank, 1986\u20132005.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women identified from the <jats:styled-content style=\"fixed-case\">AMND<\/jats:styled-content> database (<jats:italic>n<\/jats:italic> = 37 776) were classified into exposed (<jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> in first pregnancy; <jats:italic>n<\/jats:italic> = 1979) and unexposed (no <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> in first pregnancy; <jats:italic>n<\/jats:italic> = 35 797) cohorts. Each cohort (exposed <jats:italic>n<\/jats:italic> = 1174; unexposed <jats:italic>n<\/jats:italic> = 20 860) was followed up until December 2012 for next singleton pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Second pregnancy, miscarriage, pregnancy\u2010induced hypertension (<jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content>), pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>), antepartum haemorrhage (<jats:styled-content style=\"fixed-case\">APH<\/jats:styled-content>) and postpartum haemorrhage, repeat <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content>, type of labour, mode of delivery, preterm delivery, low birth weight (<jats:styled-content style=\"fixed-case\">LBW<\/jats:styled-content>), admission to neonatal unit, neonatal infections and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> in the first singleton pregnancy was associated with an equal likelihood of second pregnancy but with a significantly increased risk of adverse outcomes in the next singleton pregnancy: <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)): 6.6 (5.4\u20137.9)], <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> [2.4 (1.7\u20133.5)], instrumental [2.2 (1.7\u20132.8)] and caesarean delivery [1.8 (1.5\u20132.3)], <jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content> [1.5 (1.2\u20131.9)] and <jats:styled-content style=\"fixed-case\">APH<\/jats:styled-content> [1.3 (1.1\u20131.6)] in the mother, and neonatal infection [5.4 (1.4\u201320.3)], death [2.6 (1.0\u20136.7)], admission to neonatal unit [2.4 (2.0\u20132.9)], preterm delivery [2.3 (1.8\u20132.9)] and <jats:styled-content style=\"fixed-case\">LBW<\/jats:styled-content> [1.44 (1.1\u20131.9)]. Even in women without a recurrent <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content>, there was still a significant increase in <jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content> [1.4 (1.1\u20131.8)], <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> [2.3 (1.6\u20133.5)], instrumental [2.2 (1.7\u20132.9)] and caesarean delivery [1.9 (1.5\u20132.4)], and neonatal unit admission [1.6 (1.3\u20132.0)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> in the first pregnancy is associated with significant adverse maternal and perinatal outcomes in the next pregnancy, but not reduced likelihood of second pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> in the first singleton pregnancy increases risk of adverse maternal and perinatal outcomes in the next singleton pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14462","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T10:25:03Z","timestamp":1482920703000},"page":"1698-1707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Preterm prelabour rupture of membranes: a retrospective cohort study of association with adverse outcome in subsequent pregnancy"],"prefix":"10.1111","volume":"124","author":[{"given":"IM","family":"Aris","sequence":"first","affiliation":[{"name":"Singapore Institute for Clinical Sciences Agency for Science, Technology and Research Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Logan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Choolani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Obstetric Epidemiology Division of Applied Health Sciences University of Aberdeen Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_2_7_3_1","unstructured":"Royal College of Obstetricians and Gynaecology.Green\u2010top guideline no 44 preterm prelabour rupture of membranes.2006 pp.1\u201312[www.rcog.org.uk\/en\/guidelines-research-services\/guidelines\/]. 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