{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:13:01Z","timestamp":1777587181887,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["09\/22\/122"],"award-info":[{"award-number":["09\/22\/122"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Objective<\/jats:title>Women with overactive bladder (OAB<\/jats:styled-content>) often undergo urodynamics before invasive treatments are considered. Ultrasound measurement of bladder wall thickness (BWT<\/jats:styled-content>) is a less invasive, less expensive and widely available test. It has the potential to diagnose the presence of detrusor overactivity (DO<\/jats:styled-content>). We aimed to evaluate the accuracy of BWT<\/jats:styled-content> in the diagnosis of DO<\/jats:styled-content>.<\/jats:p><\/jats:sec>Design<\/jats:title>Prospective cohort study.<\/jats:p><\/jats:sec>Setting<\/jats:title>Twenty\u2010two UK<\/jats:styled-content> clinics (university and district general hospitals).<\/jats:p><\/jats:sec>Methods<\/jats:title>Consecutive eligible women with OAB<\/jats:styled-content> symptoms had transvaginal ultrasound to estimate BWT<\/jats:styled-content> (index test). The reference standard for the diagnosis of DO<\/jats:styled-content> was urodynamic testing with multichannel subtracted cystometry.<\/jats:p><\/jats:sec>Main outcome measures<\/jats:title>The sensitivity, specificity and likelihood ratios using a BWT<\/jats:styled-content> threshold of \u22655 mm were used to indicate the presence of DO<\/jats:styled-content>, and the area under the receiver operating characteristics (ROC<\/jats:styled-content>) curve to give an overall estimate of BWT<\/jats:styled-content> accuracy.<\/jats:p><\/jats:sec>Results<\/jats:title>Between March 2011 and 2013, 644\/687 (94%) women recruited had both tests. The mean age was 52.7 years (standard deviation 13.9) and DO<\/jats:styled-content> was diagnosed in 399\/666 (60%) women. BWT<\/jats:styled-content> had a sensitivity of 43% [95% confidence interval (CI<\/jats:styled-content>) 38\u201348%], specificity of 62% (95% CI<\/jats:styled-content> 55\u201368%), and likelihood ratios of 1.11 (95% CI<\/jats:styled-content> 0.92\u20131.35) and 0.93 (95% CI<\/jats:styled-content> 0.82\u20131.06) for positive and negative tests, respectively. The area under the ROC<\/jats:styled-content> curve was 0.53 (95% CI<\/jats:styled-content> 0.48\u20130.57). Extensive sensitivity analyses and subgroup analyses were carried out, but did not alter the interpretation.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>BWT<\/jats:styled-content> is not a good replacement test for urodynamics in women with overactive bladder.<\/jats:p><\/jats:sec>Tweetable abstract<\/jats:title>Bladder wall thickness is not a good replacement test for urodynamics in women with overactive bladder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14503","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T04:24:11Z","timestamp":1486527851000},"page":"1422-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Ultrasound bladder wall thickness and detrusor overactivity: a multicentre test accuracy study"],"prefix":"10.1111","volume":"124","author":[{"given":"P","family":"Latthe","sequence":"first","affiliation":[{"name":"Institute of Metabolism and Systems Biology 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