{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:27:17Z","timestamp":1770812837004,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"N\u00eemes University Clinical Research Department"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether cranberries are able to prevent postoperative urinary bacteriuria in patients undergoing pelvic surgery and receiving transurethral catheterisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised, double\u2010blind, placebo\u2010controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>French tertiary Care centre, University Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 272 women undergoing pelvic surgery aged 18 or older.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants undergoing pelvic surgery were randomised to 36\u00a0mg cranberry (proanthocyanidins, <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>) or placebo once daily for 10\u00a0days. Statistical analysis was performed by a chi\u2010square test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary and secondary outcomes were postoperative bacteriuria, defined by a positive urine culture, within the first 15 and 40\u00a0days, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and fifty\u2010five participants received the intended treatment: 132 (51.8%) received <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content> and 123 (48.2%) received placebo. There were no significant differences in baseline demographics, intra\u2010operative characteristics or duration and type of catheterisation between the two groups. <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content> prophylaxis did not reduce the risk of bacteriuria treatment within 15\u00a0days of surgery [27% bacteriuria with <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content> compared with 25% bacteriuria with placebo: relative risk 1.05, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.78\u20131.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.763). The same result was observed on day 40. Bacteriuria occurred more often in older women with increased length of catheterisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Immediate postoperative prophylaxis with <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content> does not reduce the risk of postoperative bacteriuria in patients receiving short\u2010term transurethral catheterisation after pelvic surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content> prophylaxis does not reduce the risk of postoperative bacteriuria in patients undergoing pelvic surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14524","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T11:46:47Z","timestamp":1486727207000},"page":"912-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cranberry capsules to prevent nosocomial urinary tract bacteriuria after pelvic surgery: a\u00a0randomised controlled trial"],"prefix":"10.1111","volume":"124","author":[{"given":"V","family":"Letouzey","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Nimes University Hospital N\u00eemes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Nimes University Hospital N\u00eemes 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