{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:23:50Z","timestamp":1788326630048,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Serous tubal intraepithelial carcinomas (<jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s) have been documented in high\u2010grade serous ovarian carcinomas (<jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s). However, the rate of association between <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s and, therefore, the fraction of <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s that are likely to have originated from the fallopian tube (<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>), has remained unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To appraise the literature describing the association between <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s and established <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Ovid <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> were searched.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Studies were included if they evaluated the frequency of <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s, and were published in an English peer\u2010reviewed journal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Appropriate studies were evaluated for their compliance with the \u2018Strengthening and Reporting of Observational Studies in Epidemiology (<jats:styled-content style=\"fixed-case\">STROBE<\/jats:styled-content>)\u2019 criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Ten articles met the study selection criteria. The reported coexistence between <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s ranged from 11% to 61% (mean: 31%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 17\u201346%). <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s were rarely found in other gynaecological cancers. Small sample size, lack of objective criteria to identify <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s and the retrospective nature of the studies contributed to the variability in reporting the rate of the association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s were identified commonly in the <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>s of women with <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>. Finding the true rate of association between <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s will require further investigations. While there is evidence that a fraction of <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s arise from the <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>s, an accurate estimate of that fraction remains to be determined. The lack of an accurate estimate of the association makes it difficult to evaluate the potential magnitude of reduction of <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s following prophylactic salpingectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A systematic review of the incidence of <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">HGSOC<\/jats:styled-content>s identifies significant methodological inconsistencies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14543","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T12:33:18Z","timestamp":1487593998000},"page":"872-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Serous tubal intraepithelial carcinomas associated with high\u2010grade serous ovarian carcinomas: a systematic review"],"prefix":"10.1111","volume":"124","author":[{"given":"F","family":"Chen","sequence":"first","affiliation":[{"name":"Ovarian Cancer Cell Laboratory The Weatherall Institute of Molecular Medicine University of Oxford Headington Oxford UK"},{"name":"School of Clinical Sciences Monash University Clayton Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Gaitskell","sequence":"additional","affiliation":[{"name":"Ovarian Cancer Cell Laboratory The Weatherall Institute of Molecular Medicine University of Oxford Headington Oxford UK"},{"name":"Cancer Epidemiology Unit Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MJ","family":"Garcia","sequence":"additional","affiliation":[{"name":"Human Genetics Group Spanish National Cancer Research Center (CNIO) Madrid Spain"},{"name":"Biomedical Network Research Centre on Rare Diseases (CIBERER) Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Albukhari","sequence":"additional","affiliation":[{"name":"Ovarian Cancer Cell Laboratory The Weatherall Institute of Molecular Medicine University of Oxford Headington Oxford UK"},{"name":"Biochemistry Department Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Tsaltas","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences Monash University Clayton Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AA","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Ovarian Cancer Cell Laboratory The Weatherall Institute of Molecular Medicine University of Oxford Headington Oxford UK"},{"name":"Nuffield Department of Obstetrics and Gynaecology University of Oxford Women's Centre John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_6_3_1","volume-title":"Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11","author":"Ferlay J","year":"2013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20121"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.11.011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1203-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.10.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.06.048"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.3023"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822f58bc"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000199"},{"key":"e_1_2_6_12_1","unstructured":"Royal College of Obstetricians and Gynaecologists.The Distal Fallopian Tube as the Origin of Non\u2010Uterine Pelvic High\u2010Grade Serous Carcinomas. 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