{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:23:05Z","timestamp":1793287385741,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the impact of gestational age (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) at diagnosis of fetal growth restriction (<jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>) on obstetric management and rates of live birth and survival for very preterm infants with early\u2010onset <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Population\u2010based cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>All maternity units in 25 French regions in 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Fetuses diagnosed with <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> before 28 weeks of gestation among singleton births between 22 and 31 weeks of gestation without severe congenital anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the effects of <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> at diagnosis on perinatal management and outcomes. We used multivariable regression to identify antenatal factors (maternal characteristics, ultrasound measurements and sex) associated with the probability of live birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcomes measures<\/jats:title><jats:p>Live birth and survival to discharge from neonatal care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 436 of 3698 fetuses were diagnosed with <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> before 28 weeks (11.8%); 66.9% were live born and 54.4% survived to discharge. 50% were live born when diagnosis occurred before 25 weeks, 66% at 25 weeks and &gt;90% at 26 and 27 weeks of gestation. In all, 94.1% of live births were by prelabour caesarean, principally for maternal indications before 26 weeks. Low <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> at diagnosis, an estimated fetal weight or abdominal circumference below the third centile and male sex were adversely associated with live birth in adjusted models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gestational age at <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> diagnosis had an impact on the probability of live birth and survival, after consideration of other perinatal characteristics. Investigations of the outcomes of births with early\u2010onset <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> need to include stillbirths and information on the <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> at which <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> is diagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Evaluations of active management of pregnancies with early onset growth restriction should include stillbirths.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14555","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T05:46:44Z","timestamp":1488865604000},"page":"1899-1906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Gestational age at diagnosis of early\u2010onset fetal growth restriction and impact on management and survival: a population\u2010based 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