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Local vulval recurrence (<jats:styled-content style=\"fixed-case\">LVR<\/jats:styled-content>) is a significant problem for these patients, and the rates of recurrence have not improved over the last three decades. Disappointingly, we still lack an understanding of how <jats:styled-content style=\"fixed-case\">LVR<\/jats:styled-content>s develop, and the best approach to prevent and manage the condition. This review discusses recent insights into the key prognostic factors that influence the risk of recurrence, focusing on the role of tumour\u2010adjacent non\u2010neoplastic epithelial disorders, which are thought to play a causative role.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A review that discusses the key prognostic factors that influence local recurrence in vulval cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14560","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T03:22:31Z","timestamp":1484277751000},"page":"946-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Current insights into the aetiology, pathobiology, and management of local disease recurrence in squamous cell carcinoma of the vulva"],"prefix":"10.1111","volume":"124","author":[{"given":"JKW","family":"Yap","sequence":"first","affiliation":[{"name":"Institute of Cancer and Genomic Sciences College of Dental and Medical School University of Birmingham Edgbaston UK"},{"name":"Department of Obstetrics and Gynaecology Birmingham City Hospital Sandwell and West Birmingham Hospitals NHS Trust Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Birmingham City Hospital Sandwell and West Birmingham Hospitals NHS Trust Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nagenthiran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Birmingham City Hospital Sandwell and West Birmingham Hospitals NHS Trust Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CW","family":"Dawson","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences College of Dental and Medical School University of Birmingham Edgbaston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DM","family":"Luesley","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences College of Dental and Medical School University of Birmingham Edgbaston UK"},{"name":"Department of Obstetrics and Gynaecology Birmingham City Hospital Sandwell and West Birmingham Hospitals NHS Trust Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Cancer Research UK Cancer Statistics.Vulval cancer incidence statistics. 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