{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T17:24:54Z","timestamp":1780766694787,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Caesarean wound complications are frequently observed in everyday practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study whether subcutaneous tissue closure following caesarean section results in decreased wound complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>We systematically searched Medline (1966\u20132016), Scopus (2004\u20132016), ClinicalTrials.gov (2008\u20132016) and Cochrane Central Register of Controlled Trials <jats:styled-content style=\"fixed-case\">CENTRAL<\/jats:styled-content> (1999\u20132016) databases together with reference lists from included studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Randomised and quasi\u2010randomised trials that investigated the impact of subcutaneous tissue suturing on wound complications following caesarean section were held eligible for inclusion. Retrospective studies and prospective nonrandomised studies were excluded from the present meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>The methodological quality of studies was assessed with the Jadad scale. Statistical meta\u2010analysis was performed with the <jats:sc>RevMan<\/jats:sc> 5.3 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Ten studies were finally included in our meta\u2010analysis, which involved 3696 women delivered by caesarean section. Re\u2010approximation of the subcutaneous tissue significantly reduced the odds of developing any type of wound complication [3811 women, random effects model (<jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>), odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 0.66, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.47\u20130.93]. The incidence of seroma was also decreased (1979 women, <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content> 0.53, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.33\u20130.84). On the other hand, the incidence of haematoma remained unaffected by subcutaneous closure (1663 women, <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content> 0.74, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.22\u20132.42) as well as the likelihood of developing a wound infection (1971 women, <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content> 0.99, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.70\u20131.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of our meta\u2010analysis suggest that subcutaneous tissue closure may benefit women undergoing caesarean section. Current data in women with high body mass index remain very limited; hence, definitive conclusions are precluded for this specific group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Subcutaneous tissue closure may benefit women undergoing caesarean section.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14593","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T07:41:41Z","timestamp":1486539701000},"page":"1018-1025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The impact of subcutaneous tissue suturing at caesarean section on wound complications: a meta\u2010analysis"],"prefix":"10.1111","volume":"124","author":[{"given":"V","family":"Pergialiotis","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research N.S. Christeas Athens University Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Prodromidou","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research N.S. Christeas Athens University Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DN","family":"Perrea","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research N.S. Christeas Athens University Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SK","family":"Doumouchtsis","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research N.S. 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