{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:31:55Z","timestamp":1785209515920,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse fibroid vascularisation measured with three\u2010dimensional (3D) power Doppler in relation to absolute fibroid volume change during 12 months of follow up and in relation to fibroid growth rate per year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective cohort study was performed between March 2012 and March 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Outpatient clinic of the <jats:styled-content style=\"fixed-case\">VU<\/jats:styled-content> medical centre, Amsterdam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population or sample<\/jats:title><jats:p>All premenopausal women diagnosed with a maximum of two fibroids with expectant management were consecutively included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three\u2010dimensional ultrasound including power Doppler was performed at baseline, 3, 6 and 12 months. Volume and vascular parameters were calculated using <jats:styled-content style=\"fixed-case\">VOCAL<\/jats:styled-content> software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The relationship between vascular index (<jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>) at baseline and fibroid volume over time was analysed using linear mixed model analyses for repeated measurements. Second, the relationship between <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> at baseline and fibroid growth rate per year was calculated using linear regression analyses. Analyses were adjusted for possible confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 66 women (mean age 42 years) completed 12 months of follow up without treatment. Baseline fibroid vascularisation (<jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>) measured with 3D power Doppler is correlated with fibroid volume at 12 months (<jats:italic>P<\/jats:italic> = 0.02 ). An increase of 1% in <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> at baseline was associated with a 7.00\u2010cm<jats:sup>3<\/jats:sup> larger fibroid volume at 12 months. Furthermore, vascularisation was also associated with fibroid growth rate per year (<jats:italic>P<\/jats:italic> = 0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In women with uterine fibroids without therapy, baseline vascularisation (<jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>) measured with 3D power Doppler is correlated with absolute fibroid volume change at 12 months and with fibroid growth rate per year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Fibroid vascularisation correlates with absolute fibroid volume change and fibroid growth rate per year.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14608","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T12:42:43Z","timestamp":1487335363000},"page":"577-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Fibroid vascularisation assessed with three\u2010dimensional power Doppler ultrasound is a predictor for uterine fibroid growth: a prospective cohort study"],"prefix":"10.1111","volume":"125","author":[{"given":"LL","family":"Nieuwenhuis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AL","family":"Keizer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Stoelinga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JWR","family":"Twisk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WJK","family":"Hehenkamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAM","family":"Br\u00f6lmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAF","family":"Huirne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.12.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.05.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2008.09.581"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.5787"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200207000-00002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7482"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808188105"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.05.011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt042"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gat007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590903015502"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg213"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11155"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22208"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(09)60209-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14668"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6138"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10122"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.11.011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12419"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.093"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2015.1015746"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.01.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347609156778"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347609156794"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0096(199603)24:3<135::AID-JCU5>3.0.CO;2-I"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(92)90079-P"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000291820"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00073-7"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1998.17.1.17"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12558"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12288"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132363"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7562"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6110"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.04.007"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114537719"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112459233"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.02.017"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2222010584"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.09.026"},{"key":"e_1_2_7_43_1","article-title":"Contrast\u2010enhanced dynamic MR imaging of uterine fibroids as a potential predictor of patient eligibility for mr guided focused ultrasound (MRgFUS) treatment for symptomatic uterine fibroids","volume":"2010","author":"Yoon SW","year":"2010","journal-title":"Obstet Gynecol Int"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.08.030"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.14608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.14608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:46:06Z","timestamp":1695548766000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.14608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/1471-0528.14608"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.14608","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]},"assertion":[{"value":"2017-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}