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Ovulation was co\u2010triggered by human chorionic gonadotropin (<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>; 1000\u00a0iu) and gonadotropin\u2010releasing hormone agonist (Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist; 0.1\u00a0mg) when dominant follicles matured. Viable embryos were cryopreserved for later frozen embryo transfer (<jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content>) in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary outcome measure was the number of oocytes retrieved. Secondary outcomes included the incidence of a premature surge in luteinising hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>), the number of viable embryos, and clinical pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of oocytes retrieved and viable embryos were similar between two groups (9.8\u00a0\u00b1\u00a06.3 versus 9.6\u00a0\u00b1\u00a05.9; 4.2\u00a0\u00b1\u00a02.6 versus 3.7\u00a0\u00b1\u00a03.0; <jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.05). No significant difference was found in clinical pregnancy rate (58.0 versus 48.7%) and live birth rate per participant (48.7 versus 42.0%; <jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.05). No premature <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> surge and ovarian hyperstimulation syndrome (<jats:styled-content style=\"fixed-case\">OHSS<\/jats:styled-content>) occurred in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Progestin\u2010primed ovarian stimulation (<jats:styled-content style=\"fixed-case\">PPOS<\/jats:styled-content>) using 4 or 10\u00a0mg of <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> per day was comparable in terms of the number of oocytes retrieved and pregnancy outcome after <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content>. The administration of 4\u00a0mg of <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> per day was sufficient to prevent an untimely LH rise in women undergoing <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>An <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> confirmed similar pregnancy outcome in P\u2010primed ovarian stimulation with a daily dose of 4 or 10\u00a0mg <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14622","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T08:19:31Z","timestamp":1489047571000},"page":"1048-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["The pregnancy outcome of progestin\u2010primed ovarian stimulation using 4 versus 10\u00a0mg of medroxyprogesterone acetate per day in infertile women undergoing <i>in\u00a0vitro<\/i> fertilisation: a randomised controlled trial"],"prefix":"10.1111","volume":"124","author":[{"given":"J","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WR","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai 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