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U2, <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> (Evalyn brush\u2122, Rovers Medical Devices B.V., Oss, the Netherlands) were also analysed. All samples were tested for <jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content> using the analytically sensitive <jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content>10\u2010<jats:styled-content style=\"fixed-case\">DEIA<\/jats:styled-content>\u2010Li<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>25 assay and the clinically validated <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>5+\/6+\u2010<jats:styled-content style=\"fixed-case\">EIA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LMNX<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Histologically confirmed <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ and hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positivity for 14 high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Samples from 91 patients were analysed. All <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) tested positive for hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SS<\/jats:styled-content>, U1, and U2 with both <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> assays. Sensitivity for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ with the <jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content>10 system was 100, 100, 95, and 100%, respectively. With the <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>5+\/6+ assay, sensitivity was 95% in all sample types. The sensitivities and specificities for both tests on each of the sample types did not significantly differ. There was 10\u201314% discordance on hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ detection using <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing of U1 shows a sensitivity similar to that of <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> or brush\u2010based <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>, and is convenient. There was substantial to almost excellent agreement between all samples on genotype with both hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> assays. There was no advantage in testing U1 compared with U2 samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Similar <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ sensitivity for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing in first\u2010void urine, physician\u2010taken smear and brush\u2010based self\u2010sample.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14682","type":"journal-article","created":{"date-parts":[[2017,4,9]],"date-time":"2017-04-09T09:06:45Z","timestamp":1491728805000},"page":"1356-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["<scp>HPV<\/scp> testing in first\u2010void urine provides sensitivity for <scp>CIN<\/scp>2+ detection comparable with a smear taken by a clinician or a brush\u2010based self\u2010sample: cross\u2010sectional data from a triage 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