{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:12:49Z","timestamp":1780726369203,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008453","name":"American Society for Parenteral and Enteral Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate complications of pregnancy, including thromboembolism, in women with extensive vascular malformations associated with Klippel\u2013Tr\u00e9naunay syndrome (<jats:styled-content style=\"fixed-case\">KTS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Nationwide cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Two tertiary expert centres and the Dutch Klippel\u2013Tr\u00e9naunay patient organisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>Adult women with <jats:styled-content style=\"fixed-case\">KTS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">KTS<\/jats:styled-content> were invited to participate in a comprehensive online survey about their obstetric history. Reference data on pregnancy outcomes and complications of non\u2010diseased women were collected from population\u2010based cohorts from the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Prevalence of complications, specifically venous thromboembolism and postpartum haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty women completed the survey. Seventeen patients did not conceive, of whom three refrained from pregnancy because of <jats:styled-content style=\"fixed-case\">KTS<\/jats:styled-content>. A total of 97 pregnancies and 86 deliveries were reported in 43 patients. <jats:styled-content style=\"fixed-case\">KTS<\/jats:styled-content>\u2010related symptoms were aggravated during pregnancy in 43% of patients. Deep vein thrombosis was present in 5.8% and pulmonary embolism was present in 2.3% of pregnancies, which was extremely high compared with the reference population (<jats:italic>P<\/jats:italic> &lt; 0.0001), with a relative risk of 108.9 (95% confidence interval, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 46.48\u2013255.03) and 106.2 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 26.97\u2013418.10), respectively. Severe postpartum haemorrhage (<jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content>) occurred in 11% of <jats:styled-content style=\"fixed-case\">KTS<\/jats:styled-content> pregnancies, compared with 5.8% of pregnancies in the reference population (relative risk, <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.81, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.97\u20133.37, <jats:italic>P<\/jats:italic> = 0.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that women with <jats:styled-content style=\"fixed-case\">KTS<\/jats:styled-content> have a significant risk of venous thromboembolic events, severe postpartum haemorrhage, and aggravation of <jats:styled-content style=\"fixed-case\">KTS<\/jats:styled-content> symptoms during pregnancy, and in early postpartum period. Obstetricians should counsel patients about these risks in the preconception phase. Antithrombotic prophylaxis should be considered in the obstetric management of patients with <jats:styled-content style=\"fixed-case\">KTS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>High risk of complications during pregnancy and labour in women with Klippel\u2013Tr\u00e9naunay syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14698","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T07:27:04Z","timestamp":1492846024000},"page":"1780-1788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Complications of pregnancy and labour in women with Klippel\u2013Tr\u00e9naunay syndrome: a nationwide cross\u2010sectional study"],"prefix":"10.1111","volume":"124","author":[{"given":"SE","family":"Horbach","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive, and Hand Surgery Academic Medical 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