{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:58:58Z","timestamp":1790211538185,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001721","name":"Rijksuniversiteit Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005075","name":"Universitair Medisch Centrum Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oophorectomy is recommended for women at increased risk for ovarian cancer. When performed at premenopausal age oophorectomy induces acute surgical menopause, with unwanted consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) and fracture prevalence after surgical menopause.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>A literature search of PubMed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> and Cochrane library was performed with no date restriction. Date of last search was March 1st, 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Primary studies reporting on <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>,<jats:italic> T<\/jats:italic>\u2010scores or fracture prevalence in women with surgical menopause and age\u2010matched control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Data were extracted on <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> (g\/cm<jats:sup>2<\/jats:sup>), <jats:italic>T<\/jats:italic>\u2010scores and fracture prevalence in women with surgical menopause and control groups. Quality was assessed by an adaptation of the Downs and Black checklist. Random effects models were used to meta\u2010analyse results of studies reporting on <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> or fracture rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Seventeen studies were included, comprising 43 386 women with surgical menopause. Ten studies provided sufficient data for meta\u2010analysis. <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> after surgical menopause was significantly lower than in premenopausal age\u2010matched women [mean difference lumbar spine, \u22120.15 g\/cm<jats:sup>2<\/jats:sup> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22120.19 to \u22120.11 g\/cm<jats:sup>2<\/jats:sup>); femoral neck, \u22120.17 g\/cm<jats:sup>2<\/jats:sup> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22120.23 to \u22120.11 g\/cm<jats:sup>2<\/jats:sup>)] but not lower than in women with natural menopause [lumbar spine, \u22120.02 g\/cm<jats:sup>2<\/jats:sup> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22120.04 to 0.00 g\/cm<jats:sup>2<\/jats:sup>); femoral neck, 0.04 g\/cm<jats:sup>2<\/jats:sup> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22120.09 to 0.16 g\/cm<jats:sup>2<\/jats:sup>)]. Hip fracture rate was not higher after surgical menopause compared with natural menopause [hazard ratio: 0.85 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.70 to 1.04)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Author's conclusions<\/jats:title><jats:p>No evident effect of surgical menopause was observed on <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and fracture prevalence compared with natural menopause. However, available studies are prone to bias and need to be interpreted with caution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Bone health after menopause: no evidence for additional effect of surgical menopause on <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and fractures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14703","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T07:30:09Z","timestamp":1493019009000},"page":"1525-1535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Bone mineral density and fractures after surgical menopause: systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"124","author":[{"given":"IE","family":"Fakkert","sequence":"first","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EM","family":"Abma","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine Department of Internal Medicine University Medical Center Groningen University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RHJA","family":"Slart","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Medical Imaging Center University Medical Center Groningen University of Groningen Groningen the Netherlands"},{"name":"Department of Biomedical Photonic Imaging University of Twente Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MJE","family":"Mourits","sequence":"additional","affiliation":[{"name":"Department of Gynaecology University Medical Center Groningen University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GH","family":"de Bock","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"193","article-title":"ACOG practice bulletin No. 7. 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