{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:03:22Z","timestamp":1793048602843,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the costs of labour induction with oral misoprostol versus Foley catheter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Economic evaluation alongside a randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Obstetric departments of six tertiary and 23 secondary care hospitals in the Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women with a viable term singleton pregnancy in cephalic presentation, intact membranes, an unfavourable cervix (Bishop score &lt;6) without a previous caesarean section, were randomised for labour induction with oral misoprostol (<jats:italic>n<\/jats:italic> = 924) or Foley catheter (<jats:italic>n<\/jats:italic> = 921).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed economic analysis from a hospital perspective. We estimated direct medical costs associated with healthcare utilisation from randomisation until discharge. The robustness of our findings was evaluated in sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Mean costs and differences were calculated per women induced with oral misoprostol or Foley catheter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean costs per woman in the oral misoprostol group and Foley catheter group were \u20ac4470 versus \u20ac4158, respectively [mean difference \u20ac312, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) \u2013\u20ac508 to \u20ac1063]. Multiple sensitivity analyses did not change these conclusions. However, if cervical ripening for low\u2010risk pregnancies in the Foley catheter group was carried out in an outpatient setting, with admittance to labour ward only at start of active labour, the difference would be \u20ac4470 versus \u20ac3489, respectively (mean difference \u20ac981, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u20ac225\u20131817).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral misoprostol and Foley catheter generate comparable costs. Cervical ripening outside labour ward with a Foley catheter could potentially save almost \u20ac1000 per woman.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Oral misoprostol or Foley catheter for induction of labour generates comparable costs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14706","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T20:25:12Z","timestamp":1493151912000},"page":"375-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Comparing induction of labour with oral misoprostol or Foley catheter at term: cost\u2010effectiveness analysis of a randomised controlled multi\u2010centre non\u2010inferiority trial"],"prefix":"10.1111","volume":"125","author":[{"given":"MLG","family":"ten Eikelder","sequence":"first","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Centre Leiden Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u2010J","family":"van Baaren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Oude Rengerink","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care Univerity Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jozwiak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Centre Leiden Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JW","family":"de Leeuw","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ikazia Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Kleiverda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Flevo Hospital Almere the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Evers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Meander Medical Centre Amersfoort the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Rijnstate Hospital Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Brons","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Medical Spectrum Twente Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KWM","family":"Bloemenkamp","sequence":"additional","affiliation":[{"name":"Wilhelmina Children's Hospital Birth Centre University Medical Centre Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BW","family":"Mol","sequence":"additional","affiliation":[{"name":"The Robinson Research Institute School of Paediatrics and Reproductive Health University of Adelaide Adelaide SA Australia"},{"name":"South Australian Health and Medical Research Institute Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,8]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"NICE guideline Induction of labour.2008[http:\/\/www.nice.org.uk\/CG070] Accessed 17 October 2015."},{"key":"e_1_2_6_3_1","unstructured":"The Health and Social Care Information Centre.NHS Maternity Statistics England 2013\u201314. [http:\/\/www.hscic.gov.uk\/catalogue\/PUB16725\/nhs-mate-eng-2013-14-summ-repo-rep.pdf] Accessed 28 October 2015."},{"key":"e_1_2_6_4_1","volume-title":"WHO recommendations for induction of labour","author":"World Health Organization","year":"2011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61998-X"},{"issue":"2","key":"e_1_2_6_6_1","first-page":"CD001997","article-title":"Elective delivery in diabetic pregnant women","author":"Boulvain M","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b48ef5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00084-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12221"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12348"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-67"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.584"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2009.07.012"},{"key":"e_1_2_6_14_1","unstructured":"Hakkaart\u2010van RoijenRL TanSS BouwmansCAM.Handleiding voor kostenonderzoek methoden en standaard kostprijzen voor economische evaluaties in de gezondheidszorg [Guidelines for Pharmaco\u2010economic Research]. Diemen College voor zorgverzekeringen (CvZ) [Health Insurance Board]; 2010."},{"key":"e_1_2_6_15_1","unstructured":"Statistics Netherlands.Statline consumer Pricing Index DenHaag\/Heerlen the Netherlands. 2015. [www.statline.nl0] Accessed 2 November 2015."},{"key":"e_1_2_6_16_1","unstructured":"College voor zorgverzekeringen (CvZ)[Health Insurance Board].Pharmacotherapeutic Compass 2013(in Dutch). Amstelveen. 2013."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0258(20001215)19:23<3219::AID-SIM623>3.0.CO;2-P"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1484-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182878b43"},{"key":"e_1_2_6_20_1","first-page":"781","article-title":"The timing of adverse events with Foley catheter preinduction cervical ripening; implications for outpatient use","volume":"31","author":"Sciscione AC","year":"2014","journal-title":"Am J Perinatol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200111000-00008"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3552(05)80187-7"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.14706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.14706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:08:05Z","timestamp":1695038885000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.14706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,8]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/1471-0528.14706"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.14706","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,8]]},"assertion":[{"value":"2017-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}