{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:11:14Z","timestamp":1793394674129,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001833","name":"Vrije Universiteit Amsterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the effectiveness of a hysteroscopic niche resection versus no treatment in women with postmenstrual spotting and a uterine caesarean scar defect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Multicentre randomised controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Eleven hospitals collaborating in a consortium for women's health research in the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Women reporting postmenstrual spotting after a caesarean section who had a niche with a residual myometrium of \u22653 mm, measured during sonohysterography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women were randomly allocated to hysteroscopic niche resection or expectant management for 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>The primary outcome was the number of days of postmenstrual spotting 6 months after randomisation. Secondary outcomes were spotting at the end of menstruation, intermenstrual spotting, dysuria, sonographic niche measurements, surgical parameters, quality of life, women's satisfaction, sexual function, and additional therapy. Outcomes were measured at 3 months and, except for niche measurements, also at 6 months after randomisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We randomised 52 women to hysteroscopic niche resection and 51 women to expectant management. The median number of days of postmenstrual spotting at baseline was 8 days in both groups. At 6 months after randomisation, the median number of days of postmenstrual spotting was 4 days (interquartile range,\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      2\u20137 days) in the intervention group and 7 days (\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      3\u201310 days) in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04); on a scale of 0\u201310, discomfort as a result of spotting had a median score of 2 (\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      0\u20137) in the intervention group, compared with 7 (\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      0\u20138) in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In women with a niche with a residual myometrium of \u22653 mm, hysteroscopic niche resection reduced postmenstrual spotting and spotting\u2010related discomfort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>A hysteroscopic niche resection is an effective treatment to reduce niche\u2010related spotting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.14733","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T10:42:45Z","timestamp":1494844965000},"page":"326-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Hysteroscopic resection of a uterine caesarean scar defect (niche) in women with postmenstrual spotting: a randomised controlled trial"],"prefix":"10.1111","volume":"125","author":[{"given":"AJMW","family":"Vervoort","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology ICaR\u2010VU Institure VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LF","family":"van der Voet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Deventer Hospital Deventer the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WJK","family":"Hehenkamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology ICaR\u2010VU Institure VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AL","family":"Thurkow","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and 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