{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:11:03Z","timestamp":1782439863996,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the therapeutic effect and safety of ultrasound\u2010guided high\u2010intensity focused ultrasound (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content>) treatment on symptomatic uterine fibroids in Black women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A feasibility study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Gynaecological department in a teaching hospital in South Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Premenopausal women with uterus fibroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six patients with 53 fibroids who underwent <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment were enrolled. The <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment information was recorded, including treatment time, sonication time and total energy. Adverse events were also observed and recorded during and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Safety and efficacy of <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> for the treatment of uterine fibroids in Black women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median volume of fibroids was 52.7 (interquartile range, 18.6\u2013177.4) cm<jats:sup>3<\/jats:sup>. According to <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment plan, total energy of 298.6\u00a0\u00b1\u00a0169.3 <jats:styled-content style=\"fixed-case\">kJ<\/jats:styled-content> (range, 76.0\u2013889.2) within treatment time of 90.3\u00a0\u00b1\u00a043.3 minutes (range, 14.0\u2013208.0), in which sonication time of 774.0\u00a0\u00b1\u00a0432.9\u00a0seconds (range, 190.0\u20132224.0) was used to ablate fibroids. The average ablation rate was 80.6\u00a0\u00b1\u00a09.7% (range, 46.5\u201394.5%). During the procedure, 69.2% of the patients reported lower abdominal pain, 57.7% sciatic\/buttock pain, 38.5% burning skin, and 34.6% transient leg pain. No severe complications were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> is feasible and safe to use to treat symptomatic uterine fibroids in Black women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Multiple uterine fibroids are more frequently detected in Black women. <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> is feasible and safe for the treatment of uterine fibroids in Black women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14738","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T22:33:52Z","timestamp":1504305232000},"page":"12-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy and safety of ultrasound\u2010guided high intensity focused ultrasound ablation of symptomatic uterine fibroids in Black women: a preliminary study"],"prefix":"10.1111","volume":"124","author":[{"given":"C","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ultrasound Engineering in Medicine Chongqing Medical University Chongqing China"},{"name":"Department of Obstetrics and Gynecology Suining Central Hospital Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chris Hani Baragwanath Academic Hospital Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZE","family":"Ngobese","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Radiology Christ Hani Baragwanath Academic Hospital Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Setzen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chris Hani Baragwanath Academic Hospital Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.1238"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1411029"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112063"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb01804.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610400024583"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.04.051"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.825607"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(98)80025-X"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090628"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2011.01339.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2015.05.016"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200107000-00006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2015.1046406"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.891110"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2517-z"},{"key":"e_1_2_10_18_1","first-page":"1503","article-title":"Uterine fibroid tumours: diagnosis and treatment","volume":"75","author":"Evans P","year":"2007","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_19_1","first-page":"271","article-title":"Uterine leiomyomata in South Western Nigeria: a clinical study of presentations and management outcome","volume":"11","author":"Okogbo FO","year":"2011","journal-title":"Afr Health Sci"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.26.2.179"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1564793"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.32.8.1353"},{"key":"e_1_2_10_23_1","first-page":"396","volume":"73","author":"Zhang L","year":"2010","journal-title":"Eur J Feasibility of magnetic resonance imaging\u2010guided high intensity focused ultrasound therapy for ablating uterine fibroids in patients with bowel lies anterior to uterus Radiol"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000650"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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