{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:27:29Z","timestamp":1787887649662,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the changes in antim\u00fcllerian hormone (<jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>) levels after ablation for symptomatic uterine fibroids and adenomyosis using ultrasound\u2010guided high\u2010intensity focused ultrasound (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Gynaecological department in multiple hospitals in South Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Patients with uterus fibroids and adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010nine women with symptomatic uterine fibroids and adenomyosis who met the inclusion criteria were enrolled in our study between January 2014 and December 2014. All patients underwent <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> ablations. Each patient was examined before and after treatment, and at 6 and 12\u00a0months after treatment by T2\u2010weighted <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> imaging (T2<jats:styled-content style=\"fixed-case\">WI<\/jats:styled-content>) and T1\u2010weighted <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> imaging (T1<jats:styled-content style=\"fixed-case\">WI<\/jats:styled-content>) with gadolinium injection. Symptom severity scores (<jats:styled-content style=\"fixed-case\">SSS<\/jats:styled-content>), Uterine Fibroid Symptom Quality of Life (<jats:styled-content style=\"fixed-case\">UFS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) questionnaire subscales, and reductions of treated volume were assessed. <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> levels before and 6\u00a0months after <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> ablation were compared to determine whether <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> ablation affected ovarian reserve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment did not affect the ovarian function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment time (mean\u00a0\u00b1\u00a0standard deviation), <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> ablation time, and treatment energy were 73.5\u00a0\u00b1\u00a025.6\u00a0minutes, 9994.7\u00a0\u00b1\u00a0386.8\u00a0seconds, and 364\u00a0713.8\u00a0\u00b1\u00a0156\u00a0350.7 Joules, respectively. <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> levels before and 6\u00a0months after <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> ablation were 2.11\u00a0\u00b1\u00a02.66 and 1.84\u00a0\u00b1\u00a02.57\u00a0<jats:italic>\u03bc<\/jats:italic>g\/l, respectively. There was no significant difference in <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> level between the two time points (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> ablation for uterine fibroid and adenomyosis was effective without affecting ovarian reserve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> ablation is a safe and effective treatment for patients with uterine fibroids and adenomyosis that does not affect ovarian function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14739","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T22:33:52Z","timestamp":1504305232000},"page":"18-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Changes in anti\u2010m\u00fcllerian hormone levels as a biomarker for ovarian reserve after ultrasound\u2010guided high\u2010intensity focused ultrasound treatment of adenomyosis and uterine fibroid"],"prefix":"10.1111","volume":"124","author":[{"given":"J\u2010S","family":"Lee","sequence":"first","affiliation":[{"name":"Aegisroen Obstetric Gynaecology Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u2010Y","family":"Hong","sequence":"additional","affiliation":[{"name":"Green Cross Medical Clinic Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u2010H","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul National University Biomedical Informatics (SNUBI) and Systems Biomedical Informatics Research Center Division of Biomedical Informatics Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u2010E","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Incheon St. Mary's Hospital College of Medicine The Catholic University of Korea Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.07.030"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328359f10a"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.08.020"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.10.020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000123642.76105.6E"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02993-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00639-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0331"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.12.3065"},{"key":"e_1_2_11_11_1","unstructured":"R Core Team(2015).R: A Language and Environment for Statistical Computing.Vienna:R Foundation for Statistical Computing. 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