{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:27:56Z","timestamp":1782602876080,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effects of dexmedetomidine\u2010remifentanil with the traditional analgesia and sedation regimen midazolam\u2010remifentanil during <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment of uterine fibroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Department of Anesthesia in a single hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Patients with uterine fibroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 80 patients diagnosed with uterine fibroids and scheduled for selective <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment were randomly divided into the dexmedetomidine group (the D group) and midazolam group (the M group). At 20\u00a0minutes before the <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> procedure, patients in the D group received a loading dose of 0.8\u00a0<jats:italic>\u03bc<\/jats:italic>g\/kg dexmedetomidine, followed by a continuous intravenous infusion of 0.2\u00a0<jats:italic>\u03bc<\/jats:italic>g\/kg\/hour until the end of the operation. Patients in the M group were given a corresponding amount of 0.9% saline. Patients in the M group received a slow intravenous infusion of 0.03\u00a0mg\/kg midazolam before the procedure, an intravenous injection of 0.02\u00a0mg\/kg 30\u00a0minutes later, another 0.02\u00a0mg\/kg 60\u00a0minutes later, followed by 0.02\u00a0mg\/kg at 40\u2010minutes intervals. Patients in the D group were given a corresponding amount of 0.9% saline. During the <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> procedure, patients in both groups were administered remifentanil at an effect site concentration of 1.0\u00a0ng\/ml. Sedation and analgesia were rated using the Ramsay Sedation Scale (<jats:styled-content style=\"fixed-case\">RSS<\/jats:styled-content>) and Visual Analogue Scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) before drug administration (T1), after drug administration but before <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> (T2), at the beginning of <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> (T3), 15\u00a0minutes later (T4), 45\u00a0minutes later (T5), 75\u00a0minutes later (T6), and at the end of <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> (T7). Patient satisfaction score and Steward recovery score survey were conducted 30\u00a0minutes after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Different effects of the traditional midazolam\u2010remifentanil regimen and dexmedetomidine\u2010remifentanil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients in both groups underwent a successful <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> procedure without developing serious complications during the postoperative period. However, the D group reported significantly fewer cases of respiratory depression than the M group during <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The pause during <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> ablation in the D group was significantly shorter than that in the M group. <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> ablation intensity, the number of patients with an <jats:styled-content style=\"fixed-case\">RSS<\/jats:styled-content> of 3 or 4 measured at different time points, and the number of patients with an <jats:styled-content style=\"fixed-case\">RSS<\/jats:styled-content> of 3 or 4 measured at arousal were significantly greater in the D than the M group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Likewise, the D group scored significantly higher in the evaluation of patient satisfaction, recovery score, and surgeon satisfaction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both dexmedetomidine\u2010remifentanil and midazolam\u2010remifentanil met the requirements and ensured the safety of <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment of uterine fibroids. However, compared with the traditional midazolam\u2010remifentanil regimen, dexmedetomidine\u2010remifentanil was associated with more stable sedation in patients, more efficient <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment and higher degree of patient comfort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Dexmedetomidine\u2010remifentanil is associated with more stable sedation in patients, more efficient <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment and higher degree of patient comfort than is midazolam\u2010remifentanil.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14740","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T22:33:52Z","timestamp":1504305232000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Application of dexmedetomidine\u2010remifentanil in high\u2010intensity ultrasound ablation of uterine fibroids: a randomised study"],"prefix":"10.1111","volume":"124","author":[{"given":"X","family":"Fu","sequence":"first","affiliation":[{"name":"Haifu Hospital of the First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Huang","sequence":"additional","affiliation":[{"name":"Haifu Hospital of the First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Chen","sequence":"additional","affiliation":[{"name":"Haifu Hospital of the First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Deng","sequence":"additional","affiliation":[{"name":"Haifu Hospital of the First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Wang","sequence":"additional","affiliation":[{"name":"Haifu Hospital of the First Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"State Key Laboratory of Ultrasound Engineering in Medicine Co\u2010founded by Chongqing and the Ministry of Science and Technology Chongqing Key Laboratory of Ultrasound in Medicine and Engineering College of Biomedical Engineering Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2011.08.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2517-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2015.1071436"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2016.1212276"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-016-0721-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3186"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000141"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-7094(12)70110-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2016.31.1.125"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.02.022"},{"key":"e_1_2_11_12_1","first-page":"2787","article-title":"Effects of dexmedetomidine combined with dezocine on cognition function and hippocampal microglia activation of rats","volume":"7","author":"Wan Q","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-9-48"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2010.512609"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-010-1023-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew024"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2011.07.016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-14-113"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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