{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T10:37:18Z","timestamp":1793529438160,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of high\u2010intensity focused ultrasound (<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content>) ablation for uterine fibroids on pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Department of Gynaecology in a single centre in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Patients with uterine fibroids who wish to become pregnant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with uterine fibroids who wished become pregnant and have children, were treated using <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> from April 2011 to March 2016 at Chongqing Haifu Hospital. Pregnancy outcomes were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Pregnancy outcomes after undergoing <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment, the 78 patients had 80 pregnancies, in which 76 cases were natural pregnancies and four were test\u2010tube pregnancies. Of the 78 patients who became pregnant, nine patients had complicated primary or secondary infertility before the <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment, 13 patients had had at least two miscarriages or missed miscarriages, one patient had had a stillbirth; none had undergone other special treatment. After the <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment, the average time to pregnancy was 5.6\u00a0\u00b1\u00a02.7\u00a0months. There were 15 cases of full\u2010term normal delivery and 56 cases of caesarean, including three cases of premature caesarean. After the treatment, three patients had a miscarriage (one patient's progesterone level was lower than the normal value; and the other two miscarriages were for unknown reasons), two patients became pregnant 3\u00a0months after complete curettage of uterine cavity and had full\u2010term normal deliveries, one patient planned to use contraception after complete curettage of the uterine cavity; and one patient had her labour induced (after 13\u2010weeks pregnancy). The fetuses of all the patients developed well during both the pregnancy and child\u2010bearing without uterine rapture or perinatal and postpartum complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment can effectively treat patients with uterine fibroids who wish to have children; it could significantly reduce the preparation period for pregnancy after the operation. It can also improve the fertility of patients with a history of infertility and abnormal\u00a0pregnancy and child\u2010bearing, with no additional obstetric risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>As a noninvasive therapeutic technique, <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> safely can be used to treat patients with uterine fibroids who wish to become pregnant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14742","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T22:33:52Z","timestamp":1504305232000},"page":"30-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Pregnancy outcomes in patients with uterine fibroids treated with ultrasound\u2010guided high\u2010intensity focused ultrasound"],"prefix":"10.1111","volume":"124","author":[{"given":"M","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology of Chongqing Haifu Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology of Chongqing Haifu Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology of Chongqing Haifu Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology of Chongqing Haifu Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology of Chongqing Haifu Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"pii:0814","article-title":"Fibroids (uterine myomatosis, leiomyomas)","volume":"2015","author":"Lethaby A","year":"2015","journal-title":"BMJ Clin Evid"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01300.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2012.07.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599090"},{"key":"e_1_2_11_6_1","first-page":"303","article-title":"New methods of uterine fibroids treatment","volume":"41","author":"Marciniak A","year":"2016","journal-title":"Polski Merkuriusz Lekarski"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8826"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2015.12.001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.11.023"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.01.009"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2011.01339.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4681-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.05.018"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2015.05.016"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(99)80008-5"},{"key":"e_1_2_11_16_1","first-page":"137","article-title":"Fertility following myomectomy","volume":"48","author":"Kasum M","year":"2009","journal-title":"Acta Clin Croatica"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.10.001"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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