{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:43:14Z","timestamp":1782211394790,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between SonoVue ablation enhancement effects on high\u2010intensity focused ultrasound (<jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content>) and the concentration of SonoVue and timing of <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Two randomised\u00a0controlled\u00a0trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>An\u00a0animal centre in a university and a gynaecological department in a university hospital in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population or sample<\/jats:title><jats:p>63 rabbits and 143 patients with a solitary uterine fibroid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among the 63 rabbits, three were assigned to the control group. The other 60\u00a0were evenly assigned to three study groups pretreated with 0.03, 0.05 or 0.07\u00a0ml\/kg of SonoVue before <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment. Two points in each liver were selected to be treated with <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> and sonication started at 10, 30, 60, 90, 120, 150, 180, 210, 250 or 300\u00a0seconds after the administration of SonoVue, respectively. The 143 patients with solitary uterine fibroids were assigned to four groups: 30 patients were treated using only <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content>; the other patients were pretreated with same dosage of SonoVue and 32, 38 and 43 were treated with <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> at 1\u2010, 3\u2010, and 5\u2010minutes after administration of SonoVue, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The relation between SonoVue ablation enhancement effects on <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> and the concentration of SonoVue and timing of <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the experimental study, the highest temperature and the largest necrotic volume in the liver were observed when <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> sonication started at 60\u00a0seconds after administration of SonoVue. In the clinical study, the rate of significant grey\u2010scale changes in the 1\u2010minute SonoVue group was significantly greater than in the other three groups. The sonication time to reach massive grey\u2010scale changes measured in the 1\u2010minute SonoVue group was significantly shorter than in in the other three groups. The sonication time for ablating 1\u00a0cm<jats:sup>3<\/jats:sup> of fibroid volume in the 1\u2010minute SonoVue group was significantly shorter than in the other three groups. The acoustic energy used in treating 1\u00a0mm<jats:sup>3<\/jats:sup> of uterine fibroid in the 1\u2010minute SonoVue group was significantly less than that used in the other three groups. No major complications occurred in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SonoVue could safely be used to enhance the ablation effects of <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment, and the optimal time to begin <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> sonication seems to be 1\u00a0minute after the administration of SonoVue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>SonoVue, a microbubble contrast agent, enhanced the ablation effects of <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> treatment; the optimal time to begin <jats:styled-content style=\"fixed-case\">HIFU<\/jats:styled-content> sonication appears to be 1\u00a0minute after the administration of SonoVue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14744","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T22:33:52Z","timestamp":1504305232000},"page":"78-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Enhancing ablation effects of a microbubble contrast agent on high\u2010intensity focused ultrasound: an experimental and clinical study"],"prefix":"10.1111","volume":"124","author":[{"given":"C","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Ultrasound the First Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"State Key Laboratory of Ultrasound Engineering in Medicine Co\u2010founded by Chongqing and the Ministry of Science and Technology Chongqing Key Laboratory of Ultrasound in Medicine and Engineering College of Biomedical Engineering Chongqing Medical University Chongqing 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