{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:48:11Z","timestamp":1791262091917,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Polycystic ovary syndrome is a common cause of anovulation and infertility, and a risk factor for development of metabolic syndrome and endometrial cancer. Systematic review and meta\u2010analysis of randomised controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>) that evaluated the effects of inositol as an ovulation induction agent. We searched <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, Cochrane and <jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content> conference proceedings, Register and Meta\u2010register for <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> trials\u2019 search portal. We included studies that compared inositol with placebo or other ovulation induction agents. Quality of studies was assessed for risk of bias. Results were pooled using random effects meta\u2010analysis and findings were reported as relative risk or standardised mean differences. We included ten randomised trials. A total of 362 women were on inositol (257 on myo\u2010inositol; 105 on di\u2010chiro\u2010inositol), 179 were on placebo and 60 were on metformin. Inositol was associated with significantly improved ovulation rate (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 2.3; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u20134.7; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 75%) and increased frequency of menstrual cycles (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 6.8; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.8\u201316.6; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%) compared with placebo. One study reported on clinical pregnancy rate with inositol compared with placebo (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 3.3; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.4\u201327.1), and one study compared with metformin (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.5; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.7\u20133.1). No studies evaluated live birth and miscarriage rates. Inositol appears to regulate menstrual cycles, improve ovulation and induce metabolic changes in polycystic ovary syndrome; however, evidence is lacking for pregnancy, miscarriage or live birth. A further, well\u2010designed multicentre trial to address this issue to provide robust evidence of benefit is warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Inositols improve menstrual cycles, ovulation and metabolic changes in polycystic ovary syndrome<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14754","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T16:58:12Z","timestamp":1495731492000},"page":"299-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta\u2010analysis of randomised trials"],"prefix":"10.1111","volume":"125","author":[{"given":"J","family":"Pundir","sequence":"first","affiliation":[{"name":"Centre for Reproductive Medicine St. Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Psaroudakis","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine St. Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Savnur","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine St. Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bhide","sequence":"additional","affiliation":[{"name":"Fertility and Assisted Reproduction Homerton University Hospital Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Sabatini","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine St. Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Teede","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation Monash University Clayton Vic. 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