{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:09:19Z","timestamp":1788260959695,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71373160"],"award-info":[{"award-number":["71373160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the cost\u2010effectiveness of different strategies, including gonadotropin\u2010releasing hormone agonist (Gn\n                      <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\n                      \u2010a) and oral contraceptive therapy, for the prevention of endometriosis recurrence after conservative surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cost\u2010effectiveness analysis from a health care perspective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A health\u2010resource\u2010limited setting in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Patients who underwent conservative laparoscopic or laparotomic surgery for endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Markov model was developed for the endometriosis disease course. Clinical data were obtained from published studies. Direct medical costs and resource utilization in the Chinese health care setting were taken into account. The health and economic outcomes were evaluated over a period from treatment initiation to menopause onset. Sensitivity analyses were carried out to test the impact of various parameters and assumptions on the model output.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>\n                      Quality\u2010adjusted life years (\n                      <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>\n                      s) gained and costs from a health care perspective.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incremental cost\u2010effectiveness ratio of 6\u2010month Gn\n                      <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\n                      \u2010a therapy compared with no therapy ranged from $6,185 per\n                      <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>\n                      in deep endometriosis to $6,425 with peritoneal endometriosis. A one\u2010way sensitivity analysis showed considerable influential factors, such as remission rates and utility values. Probabilistic sensitivity analysis indicated that 6\u2010month Gn\n                      <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\n                      \u2010a therapy is cost\u2010effective in most cases at a threshold of $7,400\/\n                      <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>\n                      , regardless of the type of endometriosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Six months of therapy with Gn\n                      <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\n                      \u2010a can be a highly cost\u2010effective option for the prevention of endometriosis recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>Gonadotropin\u2010releasing hormone agonist is cost effective for the prevention of endometriosis recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.14786","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T11:22:41Z","timestamp":1497439361000},"page":"469-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Medical therapy for preventing recurrent endometriosis after conservative surgery: a cost\u2010effectiveness analysis"],"prefix":"10.1111","volume":"125","author":[{"given":"B","family":"Wu","sequence":"first","affiliation":[{"name":"Medical Decision and Economic Group Department of Pharmacy Ren Ji Hospital School of Medicine Shanghai Jiaotong University Shanghai 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