{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:42:46Z","timestamp":1788352966891,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether parents who were born small for gestational age (below the 10th birthweight centile, <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) have increased risk of severe or mild placental abruption. To assess whether a history of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> in other family members modifies this intergenerational effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective population\u2010based observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The Medical Birth Registry of Norway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>From 1967 to 2013, 785\u00a0333 mother\u2013offspring pairs, 643\u00a0066 father\u2013offspring pairs, 272\u00a0941 maternal tetrads (i.e. her offspring, sibling, and niece\/nephew), and 265\u00a0505 paternal tetrads were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cohort study based on linked data from the Medical Birth Registry of Norway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) of severe placental abruption (preterm birth, birthweight below the 10th centile, or perinatal death) and mild placental abruption (other cases) in families with <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mothers who were born <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> had increased risk of severe placental abruption (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a01.5; 95% confidence interval, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.3\u20131.8), but not mild abruption. The paternal effects were weaker. The combined effect of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> in the mother and her sibling on severe abruption was twofold (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 2.4; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.7\u20133.3) compared with birthweight centiles \u226510 for both. Similarly, the effect of adding an <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> niece\/nephew was twofold (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 2.3; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.3\u20133.9), whereas the combined effect of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> in the mother, her sibling and her niece\/nephew was fourfold (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 3.6; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.9\u20136.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women who were born <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> have an increased risk of severe placental abruption. The corresponding paternal effect was modest. A history of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> in other family members increases the generational effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Women born small for gestational age have excess risk of placental abruption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14837","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T07:06:35Z","timestamp":1501311995000},"page":"667-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Placental abruption in parents who were born small: registry\u2010based cohort study"],"prefix":"10.1111","volume":"125","author":[{"given":"S","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Clinical Science University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ebbing","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LE","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Baghestan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02088.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609047092"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609047091"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02053.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2010.01030.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.069"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.4.332"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.07.025"},{"key":"e_1_2_6_10_1","first-page":"191","article-title":"Abruptio placentae \u2010 relationship with other placental dysfunction related conditions","volume":"17","author":"Rasmussen S","year":"2007","journal-title":"Nor J Epidemiol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.02064.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb10977.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000259924.74947.aa"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.1999.00159.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01008-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.05.009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140302"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb00236.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2000.079006435.x"},{"key":"e_1_2_6_20_1","first-page":"2550","article-title":"The central population registry in medical research","volume":"122","author":"Hammer H","year":"2002","journal-title":"Tidsskr Nor Laegeforen"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.080937"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl170"},{"key":"e_1_2_6_23_1","unstructured":"RasmussenS.Abruptio placentae. 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