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The initial results of <jats:styled-content style=\"fixed-case\">MTOP<\/jats:styled-content> with mifepristone alone were disappointing; however, mifepristone can sensitise the myometrium to the action of prostaglandins. Clinical trials have shown that the sequential administration of mifepristone followed 1\u20132\u00a0days later by a prostaglandin analogue is a safe, effective, and acceptable method for <jats:styled-content style=\"fixed-case\">MTOP<\/jats:styled-content>. This article will review the events and challenges leading to the development of the current evidence\u2010based and yet off\u2010label regimen for first\u2010trimester <jats:styled-content style=\"fixed-case\">MTOP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>This article reviews the events and challenges in the development of medical termination of pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14905","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T08:27:41Z","timestamp":1504168061000},"page":"1942-1947","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of medical termination of pregnancy: a review"],"prefix":"10.1111","volume":"124","author":[{"given":"PC","family":"Ho","sequence":"first","affiliation":[{"name":"Centre of Reproductive Medicine The University of Hong Kong\u2010Shenzhen 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