{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:37:56Z","timestamp":1782538676446,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Women following unilateral oophorectomy (<jats:styled-content style=\"fixed-case\">UO<\/jats:styled-content>) are occasionally encountered during assisted reproduction treatment<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the impact of <jats:styled-content style=\"fixed-case\">UO<\/jats:styled-content> on ovarian reserve in assisted reproduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>An electronic database search was performed using PubMed, <jats:styled-content style=\"fixed-case\">EBSCO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ISI<\/jats:styled-content>, Trip, ClinicalTrial.gov and the Cochrane library followed by a manual search to identify published research between January 1978 and December 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Controlled studies that compared infertile women following <jats:styled-content style=\"fixed-case\">UO<\/jats:styled-content> undergoing <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> treatment with women with two intact ovaries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Two reviewers independently extracted the data concerning the impact of <jats:styled-content style=\"fixed-case\">UO<\/jats:styled-content> on ovarian reserve tests, ovarian response to controlled ovarian hyperstimulation and clinical pregnancy rate. Meta\u2010analysis was performed using these measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Twenty\u2010one studies were eligible for quantitative analysis. They included 1045 and 18 172 <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> cycles in women with one and two intact ovaries, respectively. Basal <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> weighted mean difference (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>) was significant (2.01 IU\/l; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.24\u20133.79, <jats:italic>P<\/jats:italic> = 0.026). Similarly, the <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> of serum E<jats:sub>2<\/jats:sub> level on the day of <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> administration was significant (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>: \u2212431 pg\/ml; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u2212616 to \u2212246, <jats:italic>P<\/jats:italic> &lt; 0.001). However, the weighted overall odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) of clinical pregnancy between women with a single ovary and women with two ovaries was comparable (overall <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.76; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.57\u20131.00, <jats:italic>P<\/jats:italic> = 0.054). All eligible studies were retrospectively conducted and the heterogeneity among ovarian response measures was high.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Available pooled data supports an adverse effect of <jats:styled-content style=\"fixed-case\">UO<\/jats:styled-content> on ovarian reserve involving the quantity but not the quality of the ovarian pool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Review finds women with one ovary removed have less <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> capacity but the same pregnancy rate as women with two ovaries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.14913","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T11:28:02Z","timestamp":1504610882000},"page":"26-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The impact of unilateral oophorectomy on ovarian reserve in assisted reproduction: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"125","author":[{"given":"JS","family":"Younis","sequence":"first","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics &amp; Gynecology Poriya Medical Center Tiberias Israel"},{"name":"Faculty of Medicine in Galilee Bar\u2010Ilan University Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Naoum","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics &amp; Gynecology Poriya Medical Center Tiberias Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Salem","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics &amp; Gynecology Poriya Medical Center Tiberias Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Perlitz","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics &amp; Gynecology Poriya Medical Center Tiberias Israel"},{"name":"Faculty of Medicine in Galilee Bar\u2010Ilan University Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Izhaki","sequence":"additional","affiliation":[{"name":"Department of Evolutionary and Environmental Biology University of Haifa Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0b013e3182a3ff45"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Delayed childbearing: more women are having their first child later in life","volume":"21","author":"Matthews TJ","year":"2009","journal-title":"NCHS Data Brief"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr040"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den106"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1742-4755-11-37","article-title":"Demographic relevancy of increased use of assisted reproduction in European countries","volume":"11","author":"Kocourkova J","year":"2014","journal-title":"Reprod Health"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der092"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13048-015-0204-9","article-title":"The Bologna criteria for poor ovarian response: a contemporary critical appraisal","volume":"8","author":"Younis JS","year":"2015","journal-title":"J Ovarian Res"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.2.141"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_10_12_1","unstructured":"www.cebm.brown.edu\/openmeta"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00201.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0015-0282(16)48982-X","article-title":"Comparison of follicular response in patients with one or two ovaries in a program of in vitro fertilization","volume":"44","author":"Alper MM","year":"1985","journal-title":"Fertil Steril"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)47772-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0015-0282(16)59351-0","article-title":"In vitro fertilization and embryo transfer in patients with one ovary","volume":"48","author":"Dodds WG","year":"1987","journal-title":"Fertil Steril"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0015-0282(16)59172-9","article-title":"Results of in vitro fertilization attempts in patients with one or two ovaries","volume":"47","author":"Boutteville C","year":"1987","journal-title":"Fertil Steril"},{"key":"e_1_2_10_18_1","first-page":"359","article-title":"Comparison of in vitro fertilization results in women with one or two ovaries","volume":"32","author":"Dodson MG","year":"1987","journal-title":"J Reprod Med"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0015-0282(16)59296-6","article-title":"Comparison of follicular fluid hormones in patients with one or two ovaries participating in a program of in vitro fertilization","volume":"48","author":"Alper MM","year":"1987","journal-title":"Fertil Steril"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01555378"},{"key":"e_1_2_10_21_1","first-page":"277","article-title":"Effects of previous ovarian surgery on the follicular response to ovulation induction in an in vitro fertilization program","volume":"34","author":"Hornstein MD","year":"1989","journal-title":"J Reprod Med"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/oxfordjournals.humrep.a136915","article-title":"Inhibin and renin in follicular fluids of patients with one or two ovaries stimulated with a GnRH agonist and gonadotrophins","volume":"4","author":"Pampfer S","year":"1989","journal-title":"Hum Reprod"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54967-X"},{"key":"e_1_2_10_24_1","first-page":"270","article-title":"Ovulation induction with GnRH agonist and human menopausal gonadotropins: response in patients with one versus two ovaries","volume":"38","author":"Penzias AS","year":"1993","journal-title":"Int J Fertil Menopausal Stud"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02211149"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.2.298"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00155-4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1341-8076.2003.00128.x","article-title":"The outcomes of assisted reproductive technology cycles in patients with one or two ovaries","volume":"29","author":"Levi R","year":"2003","journal-title":"J Obstet Gynaecol"},{"key":"e_1_2_10_29_1","first-page":"89","article-title":"An evaluation of the multiple dose protocol of cetrorelix in single ovary women","volume":"17","author":"Asimakopoulos B","year":"2003","journal-title":"In Vivo"},{"key":"e_1_2_10_30_1","first-page":"S404","article-title":"ICSI performance of women with single ovary","volume":"86","author":"Esinler I","year":"2006","journal-title":"Fertil Steril"},{"key":"e_1_2_10_31_1","first-page":"698","article-title":"Treatment outcome of women with a single ovary undergoing in vitro fertilisation cycles","volume":"51","author":"Hendricks MS","year":"2010","journal-title":"Singapore Med J"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.11.019"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108343"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/5.5.546"},{"key":"e_1_2_10_35_1","first-page":"25","article-title":"Women with one ovary in in vitro fertilisation","volume":"45","author":"Asimakopoulos B","year":"2003","journal-title":"Folia Med (Plovdiv)"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00404-012-2577-y","article-title":"Women with one ovary in assisted reproduction technologies: a review of the literature","volume":"286","author":"Bouchlariotou S","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2010.538098"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90574-X"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009861"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.04.002"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu026"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(94)01969-E"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00429-9"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00696.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1258\/mi.2010.010022","article-title":"The age of ovarian failure following premenopausal hysterectomy with ovarian conservation","volume":"16","author":"Read MD","year":"2010","journal-title":"Menopause Int"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318236fd12"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des391"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.12.001"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/humrep\/14.4.889","article-title":"Clinical outcome after unilateral oophorectomy in patients with polycystic ovary syndrome","volume":"14","author":"Kaaijk EM","year":"1999","journal-title":"Hum Reprod"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.8.1694"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.9.1921"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.123"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.03.045"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1558"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000078"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.4.339"},{"key":"e_1_2_10_57_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00006250-200801000-00039","article-title":"ACOG Practice Bulletin No. 89. Elective and risk\u2010reducing salpingo\u2010oophorectomy","volume":"111","year":"2008","journal-title":"Obstet Gynecol"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f5ec9d"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318236fe61"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der286"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.14913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.14913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:22:38Z","timestamp":1695547358000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.14913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,3]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/1471-0528.14913"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.14913","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,3]]},"assertion":[{"value":"2017-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}