{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:37:33Z","timestamp":1787981853317,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002833","name":"Cerebra","doi-asserted-by":"publisher","award":["RG.OBGY.485799"],"award-info":[{"award-number":["RG.OBGY.485799"]}],"id":[{"id":"10.13039\/501100002833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002833","name":"Cerebra","doi-asserted-by":"publisher","award":["1089812"],"award-info":[{"award-number":["1089812"]}],"id":[{"id":"10.13039\/501100002833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the microarchitecture of the cervix using high\u2010resolution diffusion tensor (<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>) magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Leeds, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>Women undergoing hysterectomy for benign pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Ex\u2010vivo <\/jats:italic><jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> measurements were obtained using a 9.4\u2010T Bruker nuclear magnetic resonance (<jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content>) spectrometer on seven fixed human cervices obtained at hysterectomy. A deterministic fibre\u2010tracking algorithm was used to indirectly visualise underlying fibre organisation. Inter\u2010regional differences in tissue structure were sought using quantitative measurements of diffusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>The identification of an occlusive structure in the region corresponding to the internal cervical os.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fibre tracking demonstrated two regions: an outer circular and inner longitudinal layer. The total circumferential tract volume (<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>) was greatest in the proximal region of the cervix (<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>: proximal, 271 \u00b1 198 mm<jats:sup>3<\/jats:sup>; middle, 186 \u00b1 119 mm<jats:sup>3<\/jats:sup>; distal, 38 \u00b1 36 mm<jats:sup>3<\/jats:sup>). Fractional anisotropy (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>) and apparent diffusion coefficient (<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>) measurements were significantly different between regions in all samples (<jats:italic>P<\/jats:italic> &lt; 0.0005), indicating greater tract density and organisation towards the internal os.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fibre tracking infers a system of dense, well\u2010defined, encircling fibres in the proximal region of the cervix, corresponding to the location of the internal os. These findings may provide evidence of specific anatomic microarchitecture within the cervix able to resist intrauterine forces associated with pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Diffusion\u2010tensor <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> derived tractography identified well\u2010defined encircling fibres at the internal os.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15002","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T16:32:42Z","timestamp":1509035562000},"page":"812-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Diffusion tensor imaging determines three\u2010dimensional architecture of human cervix: a cross\u2010sectional study"],"prefix":"10.1111","volume":"125","author":[{"given":"JP","family":"Nott","sequence":"first","affiliation":[{"name":"Division of Women's and 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