{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:58:14Z","timestamp":1792004294361,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the pregnancy outcomes in a cohort of women who failed to obtain a result in non\u2010invasive prenatal testing (<jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Historical cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A multicentre private practice in Sydney, Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women who failed to obtain a result from NIPT (<jats:italic>n<\/jats:italic> = 131).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The maternal characteristics, antenatal investigations and pregnancy outcomes for these women were compared with those who obtained a result at the same practice and to the general Australian obstetric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Antenatal investigations: pregnancy\u2010associated plasma protein\u2010A (<jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A), free <jats:italic>\u03b2<\/jats:italic>\u2010human chorionic gonadotrophin (<jats:italic>\u03b2<\/jats:italic>\u2010hCG), placental growth factor (PlGF), uterine artery pulsatility index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>), mean arterial pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>). Pregnancy outcomes: chromosomal abnormality, pre\u2010eclampsia, gestational diabetes, small\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>), preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 1.1% of <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content> samples failed to return a result. This cohort was significantly older and had significantly increased weight compared with the general Australian obstetric population. Pregnancy outcomes were available for 94% of the cohort. There were significantly higher rates of chromosomal aneuploidies (6.5% versus 0.2%, <jats:italic>P<\/jats:italic> &lt; 0.0001), pre\u2010eclampsia (11% versus 1.5%, <jats:italic>P<\/jats:italic> &lt; 0.0001) and gestational diabetes (23% versus 7.5%, <jats:italic>P<\/jats:italic> &lt; 0.0001) compared with the general obstetric population. Rates of preterm delivery and <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> were elevated but did not reach significance. Antenatal investigations demonstrated decreased <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A MoM (0.75 versus 1.14, <jats:italic>P<\/jats:italic> &lt; 0.0001), decreased free <jats:italic>\u03b2<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> (0.71 versus 1.01, <jats:italic>P<\/jats:italic> &lt; 0.0001) and increased uterine artery <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> (1.79 versus 1.65, <jats:italic>P<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women who fail to obtain a result from <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content> are at increased risk of adverse pregnancy outcomes, in particular chromosomal aneuploidy, gestational diabetes and pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Funding<\/jats:title><jats:p>None received.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Women who fail to obtain a result from cell\u2010free <jats:styled-content style=\"fixed-case\">DNA NIPT<\/jats:styled-content> are at increased risk of adverse pregnancy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15006","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T08:46:46Z","timestamp":1509526006000},"page":"848-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Implications of failure to achieve a result from prenatal maternal serum cell\u2010free <scp>DNA<\/scp> testing: a historical cohort study"],"prefix":"10.1111","volume":"125","author":[{"given":"N","family":"Chan","sequence":"first","affiliation":[{"name":"Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u2010E","family":"Smet","sequence":"additional","affiliation":[{"name":"Sydney Ultrasound for Women Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sandow","sequence":"additional","affiliation":[{"name":"Sydney Ultrasound for Women Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"da Silva Costa","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women Melbourne VIC Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"McLennan","sequence":"additional","affiliation":[{"name":"Sydney Ultrasound for Women Sydney NSW Australia"},{"name":"Discipline of Obstetrics, Gynaecology and Neonatology Faculty of Medicine University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02174-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.12.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.02.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.233312"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.11.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12117"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12432"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17484"},{"key":"e_1_2_7_10_1","first-page":"432","article-title":"Noninvasive prenatal testing","volume":"43","author":"Woolcock J","year":"2014","journal-title":"Aust Fam Physician"},{"key":"e_1_2_7_11_1","first-page":"2582","article-title":"Cell\u2010free DNA analysis for noninvasive examination of trisomy","volume":"373","author":"Norton ME","year":"2015","journal-title":"N Engl J Med"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7120"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4119"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12331"},{"key":"e_1_2_7_15_1","unstructured":"Illumina.Laboratory experience using Illumina next\u2010generation sequencing for noninvasive prenatal testing. Application Note: Reproductive and Genetic Health;2015."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17399"},{"key":"e_1_2_7_17_1","volume-title":"New South Wales Mothers and Babies 2014","year":"2016"},{"key":"e_1_2_7_18_1","volume-title":"Australia's Mothers and Babies 2012","year":"2014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.11331"},{"key":"e_1_2_7_20_1","volume-title":"Maternal and Perinatal Mortality and Morbidity in Queensland","author":"Humphrey MCPF","year":"2013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000361021"},{"key":"e_1_2_7_22_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2016"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000476311.74309.ae"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15851"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.207951"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.3118"},{"key":"e_1_2_7_27_1","article-title":"Factors affecting cell\u2010free DNA fetal fraction and the consequences for test accuracy","author":"Scott FP","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2008.00860.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00115.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12513"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14715"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14694"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000363"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14791"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.12.019"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.063"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.05.025"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14671"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1645"},{"key":"e_1_2_7_40_1","first-page":"25","article-title":"Preventing pre\u2010eclampsia","volume":"16","author":"McLennan A","year":"2014","journal-title":"O&G Magazine"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236355"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.023"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.27"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14666"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.15006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.15006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:15:52Z","timestamp":1694067352000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.15006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,6]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/1471-0528.15006"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.15006","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,6]]},"assertion":[{"value":"2017-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}