{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:05:34Z","timestamp":1787508334596,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201011\u2010EQPX\u20100038"],"award-info":[{"award-number":["ANR\u201011\u2010EQPX\u20100038"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","award":["00050329"],"award-info":[{"award-number":["00050329"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["SPF20160936356"],"award-info":[{"award-number":["SPF20160936356"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,8]]},"abstract":"\n Objectives<\/jats:title>\n \n To investigate the efficacy of antenatal corticosteroid (\n ACS<\/jats:styled-content>\n ) therapy on short\u2010term neonatal outcomes in preterm twins, and further document the influence of the\n ACS<\/jats:styled-content>\n \u2010to\u2010delivery interval.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n EPIPAGE\u20102 is a nationwide observational multicentre prospective cohort study of neonates born between 22 and 34 completed weeks of gestation.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n All French maternity units, except in a single administrative region, between March and December\u00a02011.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n A total of 750 twin neonates born between 24 and 31\u00a0weeks of gestation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Exposure to\n ACS<\/jats:styled-content>\n s was examined in four groups: single complete course, with an\n ACS<\/jats:styled-content>\n administration\u2010to\u2010delivery interval of \u22647\u00a0days; single complete course, with an\n ACS<\/jats:styled-content>\n \u2010to\u2010delivery interval of >7\u00a0days; repeated courses; or no\n ACS<\/jats:styled-content>\n treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n \n Neonatal outcomes analysed were severe bronchopulmonary dysplasia, periventricular leukomalacia or intraventricular haemorrhage grade\u00a0\n III<\/jats:styled-content>\n \/\n IV<\/jats:styled-content>\n , in\u2010hospital mortality, and a composite indicator of severe outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with no\n ACS<\/jats:styled-content>\n s, in multivariable analysis, a single course of\n ACS<\/jats:styled-content>\n s with an administration\u2010to\u2010delivery interval of \u22647\u00a0days was significantly associated with a reduced rate of periventricular leukomalacia or intraventricular haemorrhage grade\u00a0\n III<\/jats:styled-content>\n \/\n IV<\/jats:styled-content>\n (aOR 0.2; CI 95% 0.1\u20130.5), in\u2010hospital mortality (0.3; 0.1\u20130.6), and the composite indicator (0.1; 0.1\u20130.3), whereas a single course of\n ACD<\/jats:styled-content>\n s with an administration\u2010to\u2010delivery interval of >7\u00a0days did not significantly reduce the frequency of in\u2010hospital mortality (0.7; 0.3\u20131.8). No significant differences in terms of benefit or risk were found when comparing repeated courses with a single complete course.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In preterm twins, a single complete course of antenatal corticosteroids was associated with an improvement of severe neurological outcome, whereas reduced in\u2010hospital mortality was seen only when the\n ACS<\/jats:styled-content>\n \u2010to\u2010delivery interval was \u22647\u00a0days.\n <\/jats:p>\n <\/jats:sec>\n \n Tweetable abstract<\/jats:title>\n A single complete course of antenatal steroids reduced severe neurological morbidity in preterm twins (24\u201331\u00a0weeks).<\/jats:p>\n 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