{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:00:55Z","timestamp":1791925255412,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"publisher","award":["RFA\u201067\u201016"],"award-info":[{"award-number":["RFA\u201067\u201016"]}],"id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL076532"],"award-info":[{"award-number":["R01HL076532"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Objective<\/jats:title>Preterm birth (PTB<\/jats:styled-content>) is associated with excess maternal cardiovascular disease risk. We considered that women with PTB<\/jats:styled-content> and placental evidence of maternal malperfusion would be particularly affected.<\/jats:p><\/jats:sec>Design<\/jats:title>Pregnancy cohort study.<\/jats:p><\/jats:sec>Setting<\/jats:title>Pittsburgh, PA<\/jats:styled-content>, USA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Population<\/jats:title>Women with PTB<\/jats:styled-content> (n<\/jats:italic> = 115) and term births (n<\/jats:italic> = 210) evaluated 4\u201312 years after pregnancy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cardiometabolic risk markers were compared in women with prior PTB<\/jats:styled-content> versus term births; pre\u2010eclampsia and growth restriction cases were excluded. Placental evidence of maternal vascular malperfusion (vasculopathy, infarct, advanced villous maturation, perivillous fibrin, intervillous fibrin deposition), acute infection\/inflammation (chorioamnionitis, funisitis, deciduitus) and villitis of unknown aetiology (chronic inflammation) was used to classify PTB<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Main outcome measures<\/jats:title>Carotid artery intima\u2010media thickness (IMT<\/jats:styled-content>), fasting lipids, blood pressure (BP<\/jats:styled-content>) and inflammatory markers measured after delivery.<\/jats:p><\/jats:sec>Results<\/jats:title>Women with PTB<\/jats:styled-content> and malperfusion lesions had higher total cholesterol (+13.5 mg\/dl) and systolic BP<\/jats:styled-content> (+4.0 mmHg) at follow up compared with women with term births, accounting for age, race, pre\u2010pregnancy BMI<\/jats:styled-content>, and smoking (P<\/jats:italic> < 0.05). Women with PTB<\/jats:styled-content> and malperfusion accompanied by inflammatory lesions had the most atherogenic profile after pregnancy (cholesterol +18.7, apolipoprotein B + 12.7 mg\/dl; all P<\/jats:italic> < 0.05), adjusted for pre\u2010pregnancy features. Carotid IMT<\/jats:styled-content> was higher in this group (+0.037 cm, P<\/jats:italic> = 0.031) accounting for pre\u2010pregnancy factors; differences were attenuated after adjusting for BP<\/jats:styled-content> and atherogenic lipids at follow up (+0.027, P<\/jats:italic> = 0.095).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>PTB<\/jats:styled-content>s with placental malperfusion were associated with an excess maternal cardiometabolic risk burden in the decade after pregnancy. The placenta may offer insight into subtypes of PTB<\/jats:styled-content> related to maternal cardiovascular disease.<\/jats:p><\/jats:sec>Tweetable abstract<\/jats:title>Preterm births with placental malperfusion may mark women at higher cardiovascular disease risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15040","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T15:27:13Z","timestamp":1511969233000},"page":"1009-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Preterm birth with placental evidence of malperfusion is associated with cardiovascular risk factors after pregnancy: a prospective cohort study"],"prefix":"10.1111","volume":"125","author":[{"given":"JM","family":"Catov","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh School of Medicine Pittsburgh PA USA"},{"name":"Department of Epidemiology Graduate School of Public Health Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MF","family":"Muldoon","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh School of Medicine and Hypertension Center University of Pittsburgh Medical Center Heart and Vascular Institute Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SE","family":"Reis","sequence":"additional","affiliation":[{"name":"Office of Clinical Research Clinical Translational Science Institute University of Pittsburgh Pittsburgh PA USA"},{"name":"Department of Cardiology University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RB","family":"Ness","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Disease Control, Innovation The University of Texas School of Public Health Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LN","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010M","family":"Yamal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas Health Science Center at Houston School of Public Health Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas Health Science Center at Houston School of Public Health Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WT","family":"Parks","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh School of Medicine and the Magee\u2010Womens Hospital of UPMC Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015293"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.09.020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.12.022"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00324-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp131"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00838-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/b138589"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.10.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182075626"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.03.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/63.3.581"},{"key":"e_1_2_6_16_1","volume-title":"Multiple Imputation for Missing Data: Concepts and New Development","author":"Yuan Y","year":"2011"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089419"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.01.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.10.004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-7070-y"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-2020-x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-8083-2"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082081"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-3-642"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010020"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2013.4248"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.068"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.04.024"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm273"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2012.01391.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi323"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956773"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.17.2271"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000196964.24024.ea"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02660-7"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2000.00253.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.03.095"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00870-6"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.044784"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2014.10.012"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00143"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.11.022"}],"container-title":["BJOG: An International Journal of Obstetrics & Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.15040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:51:54Z","timestamp":1694998314000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.15040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,28]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/1471-0528.15040"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.15040","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,28]]},"assertion":[{"value":"2017-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}