{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:31:15Z","timestamp":1792931475978,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>During menopause women experience vasomotor and psychosexual symptoms that cannot entirely be alleviated with hormone replacement therapy (<jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content>). Besides, <jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content> is contraindicated after breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To review the evidence on the effectiveness of psychological interventions in reducing symptoms associated with menopause in natural or treatment\u2010induced menopausal women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Medline\/Pubmed, Psyc<jats:styled-content style=\"fixed-case\">INFO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AMED<\/jats:styled-content> were searched until June 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Randomised controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) concerning natural or treatment\u2010induced menopause, investigating mindfulness or (cognitive\u2010)behaviour\u2010based therapy were selected. Main outcomes were frequency of hot flushes, hot flush bother experienced, other menopausal symptoms and sexual functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Study selection and data extraction were performed by two independent researchers. A meta\u2010analysis was performed to calculate the standardised mean difference (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Twelve <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s were included. Short\u2010term (&lt;20\u00a0weeks) effects of psychological interventions in comparison to no treatment or control were observed for hot flush bother (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content> \u22120.54, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22120.74 to \u22120.35, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a018%) and menopausal symptoms (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content> \u22120.34, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22120.52 to \u22120.15, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%). Medium\u2010term (\u226520\u00a0weeks) effects were observed for hot flush bother (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content> \u22120.38, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22120.58 to \u22120.18, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a016%). [Correction added on 9\u00a0July 2018, after first online publication: there were miscalculations of the mean end point scores for hot flush bother and these have been corrected in the preceding two sentences.] In the subgroup treatment\u2010induced menopause, consisting of exclusively breast cancer populations, as well as in the subgroup natural menopause, hot flush bother was reduced by psychological interventions. Too few studies reported on sexual functioning to perform a meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Psychological interventions reduced hot flush bother in the short and medium\u2010term and menopausal symptoms in the short\u2010term. These results are especially relevant for breast cancer survivors in whom <jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content> is contraindicated. There was a lack of studies reporting on the influence on sexual functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Systematic review: psychological interventions reduce bother by hot flushes in the short\u2010 and medium\u2010term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15153","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:32:27Z","timestamp":1521117147000},"page":"330-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Mindfulness, cognitive behavioural and behaviour\u2010based therapy for natural and treatment\u2010induced menopausal symptoms: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"126","author":[{"given":"CM","family":"van Driel","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University Medical Centre Groningen Groningen the 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