{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:43:52Z","timestamp":1792172632223,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite recent efforts, the risks associated with bacterial vaginosis (<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>) or abnormal vaginal microbiota in <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> patients are not well\u2010established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to evaluate the risks associated with <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> patients using meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Following preliminary searches to find relevant keywords and Me<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content> terms, a systematic search was performed in PubMed (<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>) in September 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>The population was infertile women attending <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> treatment. The exposure was <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content> or abnormal vaginal microbiota. Outcomes included live birth rate, early spontaneous abortion rate and clinical pregnancy rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Data were collected for each study and for each outcome using a summary of findings table. If appropriate, data were quantitatively assessed using meta\u2010analysis, sensitivity analysis, funnel plots and <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content> evidence assessment were performed for the above\u2010mentioned outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>A total of 12 studies were eligible, comprising a total of 2980 patients. The prevalence of <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content> was 16% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 15\u201318%) in the general study population and tubal factor infertility was highly prevalent in patients diagnosed with <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content> compared with normal vaginal microbiota patients (<jats:italic>P<\/jats:italic> = 0.001). Despite a significant association with early spontaneous abortion [relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) 1.68, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.24\u20132.27], <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content> did not significantly impact the live birth rate (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.47, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.96\u20131.57) or the clinical pregnancy rate (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.93, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.75\u20131.15).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content> is associated with tubal factor infertility and early spontaneous abortion. However, the quality of evidence was very low and the equivocal results justify the need for further research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Abnormal vaginal microbiota is associated with early spontaneous abortion in <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15178","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T14:14:39Z","timestamp":1519308879000},"page":"200-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Reproductive outcome of patients undergoing in vitro fertilisation treatment and diagnosed with bacterial vaginosis or abnormal vaginal microbiota: a systematic <scp>PRISMA<\/scp> review and meta\u2010analysis"],"prefix":"10.1111","volume":"126","author":[{"given":"T","family":"Haahr","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"The Fertility Clinic Skive Skive Regional Hospital Skive Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zacho","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"The Fertility Clinic Skive Skive Regional Hospital Skive Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Br\u00e4uner","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"The Fertility Clinic Skive Skive Regional Hospital Skive Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Shathmigha","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"The Fertility Clinic Skive Skive Regional Hospital Skive Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Skov Jensen","sequence":"additional","affiliation":[{"name":"Microbiology and Infection Control Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Humaidan","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"The Fertility Clinic Skive Skive Regional Hospital Skive Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00075-15"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91112-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.2.297-301.1991"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02347-13"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-1039-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008599"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.11.043"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053997"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00901-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.09.075"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew026"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det096"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.03.022"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1770-z"},{"key":"e_1_2_6_18_1","unstructured":"Sch\u00fcnemannBGuyatt Oxman. 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