{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:21:53Z","timestamp":1778977313966,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T00:00:00Z","timestamp":1523750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010HD086742"],"award-info":[{"award-number":["R01\u2010HD086742"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03\u2010HD090315"],"award-info":[{"award-number":["R03\u2010HD090315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21\u2010HD072326"],"award-info":[{"award-number":["R21\u2010HD072326"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32\u2010HD052458"],"award-info":[{"award-number":["T32\u2010HD052458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the extent to which lubricant use during intercourse is associated with time to pregnancy (<jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Denmark and North America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 6467 women aged 18\u201349 years who were not using contraception or fertility treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We pooled data from two continuing prospective cohort studies of pregnancy planners in Denmark (2011\u20132017) and North America (2013\u20132017). Female participants completed bimonthly questionnaires for 12 months or until they reported pregnancy. After restricting the study to women without a history of infertility who had been trying to conceive for six or fewer cycles at enrollment, 6467 women were retained for analysis. Self\u2010reported lubricant use was categorised as water\u2010based\/not <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> balanced, water\u2010based\/<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> balanced \u2018fertility friendly\u2019, silicone\u2010based, oil\u2010based, or a combination of these. We used proportional probability models to calculate fecundability ratios (<jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>s) and 95% confidence intervals (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) for the association between lubricant use and fecundability, after adjusting for cohort and sociodemographic and lifestyle factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>Fecundability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 17.5% of participants reported the use of lubricants, most commonly water\u2010based\/not <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> balanced (11.4%). Compared with non\u2010use of lubricants, <jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>s were 1.02 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.93\u20131.11) for water\u2010based\/not <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010balanced lubricant use, 1.01 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.86\u20131.18) for water\u2010based\/<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> balanced \u2018fertility friendly\u2019 lubricant use, 1.23 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.94\u20131.61) for oil\u2010based lubricant use, and 1.27 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.93\u20131.73) for silicone\u2010based lubricant use. Associations between oil\u2010based lubricant use and fecundability were inconsistent across subgroups of study cohort, age, parity, and intercourse frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lubricant use was not associated with reduced fecundability in the preconception cohorts of pregnancy planners studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Lubricant use during intercourse was not associated with time to pregnancy in a study of pregnancy planners.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15218","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T15:19:50Z","timestamp":1521127190000},"page":"1541-1548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lubricant use during intercourse and time to pregnancy: a prospective cohort study"],"prefix":"10.1111","volume":"125","author":[{"given":"KA","family":"McInerney","sequence":"first","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KA","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EE","family":"Hatch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EM","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AZ","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KJ","family":"Rothman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health Boston MA USA"},{"name":"RTI Health Solutions Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HT","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health Boston MA USA"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TM","family":"Snerum","sequence":"additional","affiliation":[{"name":"Pediatric Department Regional Hospital Viborg Viborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LA","family":"Wise","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01052.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2005.14.424"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12427"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00127-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31825b87ae"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(83)90069-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90457-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)41350-6"},{"key":"e_1_2_6_10_1","first-page":"400","article-title":"Vaginal lubricants for the infertile couple: effect on sperm activity","volume":"41","author":"Kutteh WH","year":"1996","journal-title":"Int J Fertil Menopausal Stud"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.12.024"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-013-0168-x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.02.050"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.12.3351"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55279-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/LM0RXLDULFIF9TQ6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.01.116"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.09.011"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12201"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55810-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115211"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk027"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12073"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2007.034777"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws127"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116591"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2004.07.003"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901548"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11689.x"},{"key":"e_1_2_6_31_1","volume-title":"SAS\/Stat 9.3 user's guide","author":"SAS Institute","year":"2011"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12245"},{"key":"e_1_2_6_33_1","volume-title":"Human Reproductive Biology","author":"Lopez KH","year":"2014"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)39908-3"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/11.3.627"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi047"},{"key":"e_1_2_6_37_1","unstructured":"WesselinkAK WiseLA JanulewiczPA MikkelsenEM McCleanM TomshoK et al.Urinary concentrations of phenols and fecundability in two preconception cohort studies. Society for Epidemiologic Research 50th Annual Meeting; 2017 June 20\u201023; Seattle WA; 2017."},{"key":"e_1_2_6_38_1","unstructured":"WiseLA WesselinkAK MikkelsenEM ThayerKA McCleanM TomshoK et al.Perfluoroalkyl and polyfluoroalkyl substances and female fecundability in two preconception cohort studies. Society for Epidemiologic Research 50th Annual Meeting; 2017 June 20\u201023; Seattle WA; 2017."},{"key":"e_1_2_6_39_1","unstructured":"HatchEE WesselinkAK RosofskyA JanulewiczPA MikkelsenEM RothmanKJ et al.Urinary concentrations of phthalates and fecundability in two preconception cohort studies. Society for Epidemiologic Research 50th Annual Meeting; 2017 June 20\u201023; Seattle WA; 2017."}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.15218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.15218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T14:46:31Z","timestamp":1694875591000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.15218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,15]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/1471-0528.15218"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.15218","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,15]]},"assertion":[{"value":"2018-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}