{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:21:26Z","timestamp":1793060486380,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Placental anomalies (placenta praevia, placental abruption, morbidly adherent placenta and cord insertion anomalies) are associated with maternal and fetal morbidity and mortality. It has been suggested these might be more prevalent in pregnancies after assisted reproduction technology (<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> singleton pregnancies are associated with an increased risk of placental anomalies compared with non\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> singleton pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CENTRAL<\/jats:styled-content>, Web of Science and Scopus (January 2018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Cohort studies reporting placental anomalies in <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> singleton pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>We report pooled odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) for the comparisons: (1) <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> (spontaneously conceived), (2) <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> versus non\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> (unspecified), (3) <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> (frozen\u2010embryo transfer) versus <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, (4) <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> versus non\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> (subfertile patients). Study quality was assessed using a modified Newcastle \u2013Ottawa scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>33 low\/moderate quality studies evaluated 124 215 <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> and 6 054 729 non\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> singleton pregnancies. Risk of placenta praevia, placental abruption and morbidly adherent placenta was higher in <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> pregnancies: odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) (OR 3.76, 95% CI 3.09\u20104.59); (OR 1.87, 95% CI 1.70\u20102.06) and (OR 2.27, 95% CI 1.79\u20102.87) respectively. Risk of placenta praevia and placental abruption was higher in <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> than in non\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> (subfertile patients): (OR 2.51, 95% CI 2.12\u20102.98) and (OR 1.61, 95% CI 1.33\u20101.95) respectively. Results were similar when comparing <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> with unspecified non\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> pregnancies. Risk of placenta praevia was higher, but not significantly so, in <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> than in <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> pregnancies (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.42, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.63\u20139.30).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Singleton <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> pregnancies are associated with an increased risk of placental anomalies compared with non\u2010<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> singleton pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable Abstract<\/jats:title><jats:p>A review of over 6 million singleton pregnancies finds increased risk of placental anomalies after <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15227","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T05:01:30Z","timestamp":1525842090000},"page":"209-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Are singleton pregnancies after assisted reproduction technology (<scp>ART<\/scp>) associated with a higher risk of placental anomalies compared with non\u2010<scp>ART<\/scp> singleton pregnancies? A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"126","author":[{"given":"BG","family":"Vermey","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Buchanan","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GM","family":"Chambers","sequence":"additional","affiliation":[{"name":"National Perinatal Epidemiology and Statistics Unit Centre for Big Data Research in Health and School of Women's and Children's Health University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EM","family":"Kolibianakis","sequence":"additional","affiliation":[{"name":"Unit for Human Reproduction 1st Department of Obstetrics and Gynaecology, Medical School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bosdou","sequence":"additional","affiliation":[{"name":"Unit for Human Reproduction 1st Department of Obstetrics and Gynaecology, Medical School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MG","family":"Chapman","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney NSW Australia"},{"name":"IVF Australia South Sydney, Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"Venetis","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney NSW Australia"},{"name":"National Perinatal Epidemiology and Statistics Unit Centre for Big Data Research in Health and School of Women's and Children's Health University of New South Wales Sydney NSW Australia"},{"name":"IVF Australia South Sydney, Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"BrownS.6.5 million babies since Louise Brown. 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