{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:36:49Z","timestamp":1792417009555,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1052388"],"award-info":[{"award-number":["1052388"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001035","name":"Australian Women and Childrens Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To estimate the magnitude of the correlation between neonatal outcomes of twins and demonstrate how this information can be used in the design of randomised controlled trials (\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s) in women with twin pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Secondary analysis of data from 12\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Obstetric care in multiple countries, 2004\u20132012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population or sample<\/jats:title>\n                    <jats:p>\n                      4504 twin pairs born to women who participated in\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s to assess treatments given during pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Intraclass correlation coefficients (\n                      <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\n                      s) were estimated using log\u2010binomial and linear models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Perinatal death, respiratory distress syndrome, bronchopulmonary dysplasia, intraventricular haemorrhage, necrotising enterocolitis, sepsis, neonatal intensive care unit admission, birthweight, low birthweight and two composite measures of adverse neonatal outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\n                      s for the composite measures of adverse neonatal outcome were all above 0.5, indicating moderate to strong correlation between adverse outcomes of twins. For individual neonatal outcomes, median\n                      <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\n                      s across trials ranged from 0.13 to 0.79 depending on the outcome. An example illustrates how\n                      <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\n                      s can be used in sample size calculations for\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s in women with twin pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The correlation between neonatal outcomes of twins varies considerably between outcomes and may be lower than expected. Our\n                      <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\n                      estimates can be used for designing and analysing\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s that recruit women with twin pregnancies and for performing meta\u2010analyses that include such\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s. Researchers are encouraged to report\n                      <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\n                      s for neonatal outcomes in twins in their own\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>Correlation between neonatal outcomes of twins depends on the outcome and may be lower than expected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.15292","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:06:31Z","timestamp":1527033991000},"page":"1406-1413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Correlation between neonatal outcomes of twins depends on the outcome: secondary analysis of twelve randomised controlled trials"],"prefix":"10.1111","volume":"125","author":[{"given":"LN","family":"Yelland","sequence":"first","affiliation":[{"name":"South Australian Health and Medical Research Institute Adelaide SA Australia"},{"name":"School of Public Health The University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Schuit","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zamora","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"},{"name":"CIBER Epidemiology and Public Health and IRYCIS Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PF","family":"Middleton","sequence":"additional","affiliation":[{"name":"South Australian Health and Medical Research Institute Adelaide SA Australia"},{"name":"Robinson Research Institute School of Medicine The University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AC","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology and GROW\u2010School for Oncology and Developmental Biology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AH","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Rode","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"},{"name":"Department of Clinical Biochemistry Herlev and Gentofte Hospital Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Serra","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit Valencia Infertility Institute University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EA","family":"Thom","sequence":"additional","affiliation":[{"name":"George Washington University Biostatistics Center Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Vayssi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Paule de Viguier Hospital CHU Toulouse Toulouse France"},{"name":"UMR 1027 INSERM University of Paul Sabatier Toulouse III Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BWJ","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Monash Medical Centre Monash Health and Monash University Clayton Vic. 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