{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:22:19Z","timestamp":1793247739187,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007928","name":"Perelman School of Medicine, University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if the use of magnesium sulphate postdelivery reduces the risk of eclampsia in women with severe pre\u2010eclampsia exposed to at least 8 hours of magnesium sulphate before delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised multicentre controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Latin America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women with severe pre\u2010eclampsia that had received a 4\u2010g loading dose followed by 1 g per hour for 8 hours as maintenance dose before delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 1113 women were randomised; 555 women were randomised to continue the infusion of magnesium sulphate for 24 hours postpartum and 558 were randomised to stopping the magnesium sulphate infusion immediately after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome measures<\/jats:title><jats:p>Primary outcome was the incidence of eclampsia in the first 24 hours postdelivery. Secondary outcomes included maternal death, maternal complications, time to start ambulation and time to start lactation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The maternal characteristics at randomisation between the groups were not different. There were no differences in the rate of eclampsia; 1\/555 (0.18%) versus 2\/558 (0.35%) [relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.7, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.1\u20133.3; <jats:italic>P<\/jats:italic> = 0.50] or maternal complications between the groups (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.0, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.8\u20131.2; <jats:italic>P<\/jats:italic> = 0.76). Time to start ambulation was significantly shorter in the no magnesium sulphate group (18.1 \u00b1 10.6 versus 11.8 \u00b1 10.8 hours; <jats:italic>P<\/jats:italic> = 0.0001) and time to start lactation was equally shorter in the no magnesium sulphate group (24.1 \u00b1 17.1 versus 17.1 \u00b1 16.8 hours; <jats:italic>P<\/jats:italic> = 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with severe pre\u2010eclampsia treated with a minimum of 8 hours of magnesium sulphate before delivery do not benefit from continuing the magnesium sulphate for 24 hours postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>No benefit of continuing magnesium sulphate postpartum in severe pre\u2010eclampsia exposed to this drug for a minimum of 8 hours before delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.15320","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T13:01:07Z","timestamp":1528376467000},"page":"1304-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Is there benefit to continue magnesium sulphate postpartum in women receiving magnesium sulphate before delivery? A randomised controlled study"],"prefix":"10.1111","volume":"125","author":[{"given":"P","family":"Vigil\u2010DeGracia","sequence":"first","affiliation":[{"name":"Hospital de la Caja de Seguro Social Investigador distinguido del Sistema Nacional de Investigaci\u00f3n SENACYT Panam\u00e1 City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ludmir","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ng","sequence":"additional","affiliation":[{"name":"Hospital Jos\u00e9 Domingo de Obald\u00eda Chiriqu\u00ed Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Reyes\u2010Tejada","sequence":"additional","affiliation":[{"name":"Hospital Santo Tomas Miembro del Sistema Nacional de Investigacion SENACYT Panam\u00e1 City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Nova","sequence":"additional","affiliation":[{"name":"Hospital Nuestra Se\u00f1ora de Alta Gracia Santo Domingo  Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Beltr\u00e9","sequence":"additional","affiliation":[{"name":"Hospital Las minas Santo Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Yuen\u2010Chon","sequence":"additional","affiliation":[{"name":"Hospital Teodoro Maldonado Carbo Guayaquil Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Collantes","sequence":"additional","affiliation":[{"name":"Hospital Regional de Cajamarca Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Turcios","sequence":"additional","affiliation":[{"name":"Hospital Primero de Mayo Seguridad Social San Salvador El Salvador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Lewis","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario de la Caja de Seguro Social Panam\u00e1 Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Hospital Nacional Docente Madre Ni\u00f1o San Bartolom\u00e9 Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.09.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08778-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021180"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10090.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.12.057"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001518"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2014.11.024"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70216-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31823311c1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb14351.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01423.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","unstructured":"DuleyL G\u00fclmezogluAM Henderson\u2010SmartDJ ChouD.Magnesium sulphate and other anticonvulsants for women with pre\u2010eclampsia. 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